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Summary. New Zealand Obese (NZO) mice are eharaeterised by hyperglyeaemia, hyperinsulinaemia and obesity. The blood glucose and plasma insulin levels of these mice can be lowered to levels approaching those normally associated with non-obese mice, by the intraperitoneal implantation of pancreatic islets from albino mice which have had their fl-cells selectively destroyed by streptozotocin. Removal of these implanted islets causes the animals to revert to their original state. It would seem, therefore, that the genetic lesion responsible for the NZO state lies within the islets of Langerhans but not within the beta-cell. Its exact location is as yet unknown.

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