The current pandemic associated with the novel coronavirus (COVID-19) presents a new area of research with its own set of challenges. Creating unobtrusive remote monitoring tools for medical professionals that may aid in diagnosis, monitoring and contact tracing could lead to more efficient and accurate treatments, especially in this time of physical distancing. Audio based sensing methods can address this by measuring the frequency, severity and characteristics of the COVID-19 cough. However, the feasibility of accumulating coughs directly from patients is low in the short term. This paper introduces a novel database (NoCoCoDa), which contains COVID-19 cough events obtained through public media interviews with COVID-19 patients, as an interim solution. After manual segmentation of the interviews, a total of 73 individual cough events were extracted and cough phase annotation was performed. Furthermore, the COVID-19 cough is typically dry but can present as a more productive cough in severe cases. Therefore, an investigation of cough sub-type (productive vs. dry) of the NoCoCoDa was performed using methods previously published by our research group. Most of the NoCoCoDa cough events were recorded either during or after a severe period of the disease, which is supported by the fact that 77% of the COVID-19 coughs were classified as productive based on our previous work. The NoCoCoDa is designed to be used for rapid exploration and algorithm development, which can then be applied to more extensive datasets and potentially real time applications. The NoCoCoDa is available for free to the research community upon request. INDEX TERMS Acoustic signal processing, audio databases, audio systems, biomedical measurement, biomedical monitoring, data analysis, data collection, medical conditions, medical diagnosis, patient monitoring, smart homes.

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Pressure sensitive mats have been used in noninvasive smart monitoring for a variety of problems including breathing rate monitoring, sleep monitoring, mobility, and weight. This paper describes a proof of concept application of pressure mats to monitor fluid intake/output (fluid cycle) events during the night. The ability to more accurately track such events has potential implications for monitoring those individuals who have nocturia, a condition where a person wakes at night to urinate. Data were collected from a healthy young female subject instructed to drink as much water as was comfortable (700mL) and lie in a supine position on a mattress located directly on three pressure mats. This was compared to an initial data set collected immediately after voiding but before drinking, 30 minutes after drinking, 60 minutes after drinking and a final data set after again voiding the bladder. The additional pressure from the 700mL of water was detectible and tracked over the course of the hour-long testing session under idealized conditions. This provides a proof-of-concept that nocturnal fluid intake and bladder voiding events can be tracked using non-invasive pressure-sensitive mats, however additional testing and development is required to achieve a deployable monitoring system.

Genetic hypercalciuric stone-forming (GHS) rats, bred to maximize urine (u) calcium (Ca) excretion, demonstrate increased intestinal Ca absorption, increased bone Ca resorption and reduced renal Ca reabsorption, all leading to elevated uCa compared to the parental Sprague-Dawley (SD) rats. GHS rats have increased numbers of vitamin D receptors (VDR) at each site, with normal levels of 1,25(OH)2D3 (1,25D), suggesting their VDR is undersaturated with 1,25D. We have shown that 1,25D induces a greater increase in uCa in GHS than SD rats. To examine the effect of the increased VDR on the osseous response to 1,25D we fed GHS and SD rats an ample Ca diet and injected either 1,25D (12.5 (LD) or 25 (HD) ng/100 g body wt/d) or vehicle (veh) daily for 16d. Femoral areal bone mineral density (aBMD, by DEXA) was decreased in GHS+LD and GHS+HD relative to GHS+veh while there was no effect on SD. Vertebral aBMD was lower in GHS compared to SD and further decreased in GHS+HD. Both femoral and L6 vertebral volumetric BMD (by μCT) were lower in GHS and further reduced by HD. Histomorphometry indicated a decreased osteoclast number in GHS+HD compared to GHS+veh or SD+HD. In tibiae, GHS+HD trabecular thickness and number increased, with a 12-fold increase in osteoid volume but only a 3-fold increase in bone volume. Bone formation rate was decreased in GHS+HD relative to GHS+veh, confirming the mineralization defect. The loss of BMD and the mineralization defect in GHS rats contribute to increased hypercalciuria; if these effects persist they would result in decreased bone strength, making these bones more fracture prone. The enhanced effect of 1,25D in GHS indicates that the increased VDR are biologically active.

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