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Background: Tuberous sclerosis complex is a neurocutaneous syndrome inherited as autosomal dominant manner. It presents with CNS, dermatological manifestations and other systemic involvement. Methods: A case of male adolescent of 13 years age who presented in tertiary care OPD with strong family history of intellectual disability. The history obtained from his parents and necssary investigation work up has been done. A multidisciplinary team examined the patient and some unique features has been obtained. Results: The uniqueness of the case is it presents with profound intellectual disability, there is difficult to treat epilepsy due to combination of complex partial seizure with secondary generalization and myoclonus, eating disorder in the form of pica has been noted, spreading leg infection raises the possibility of child abuse and neglect. Conclusions: The appropriate treatment approach lies in judicious history taking. Parental counseling, the safety of patient should get the priority. Medical management should be combined with behavioural therapy, parental therapy and psychosocial rehabilitation. Genetic testing is necessary and multidisciplinary approach is required by a team comprising of but not limited to psychiatrists, clinical psychologist, special educator, pediatrician, physician, surgeons, dermatologist and ophthalmologist.

No abstract

Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer associated with an early age of onset, greater propensity towards metastasis, and poorer clinical outcomes. It accounts for 10% to 20% of newly diagnosed breast cancer cases and disproportionately affects individuals from the African American race. While TNBC is sensitive to chemotherapy, it is also prone to relapse. This is because chemotherapy successfully targets the primary TNBC tumor cell but often fails to target the subpopulation of TNBC stem cells. TNBC stem cells display cancerous traits such as cell cycle progression, survival, proliferation, apoptosis inhibition, and epithelial-mesenchymal transition. To study the cancer initiating behavior of the TNBC stem cells, we studied their underlying signaling pathways using Boolean networks(BN). BNs are effective in capturing the causal interactions taking place in signaling pathways. We built the BN from the pathway literature and used it to evaluate the efficacies of eleven targeted inhibitory drugs in suppressing cancer-promoting genes. We simulated the BN when the pathways had single or multiple mutations, with a maximum of three mutations at a time. Our findings indicated thatSTAT3, GLI, andNF-κBare the most optimal targets for inhibition. These genes are known regulators of the cancer-promoting genes in the pathway,hence our model agrees with the existing biological literature. Therefore inhibiting these three genes has the potential to prevent TNBC relapse. Additionally, our studies found that drug efficacies decreased as mutations increased in the pathway. Furthermore, we noticed that combinations of drugs performed better than single drugs.

Cloud computing simply means storing & accessing data and programs over the internet instead of your computers hard drive. The cloud is just a metaphor for the internet. An example of Cloud Computings process could also be Googles Gmail. Cloud computing is highly efficient, productive, safe & secure. Cloud computing consists of two terms One is Cloud which is a useful feature of computer technology to perform appropriate tasks. Computing may include computer hardware and software but must involve some form of a computer system. It is a type of operation of a computer that is fully dependent on exchanging computing resources rather than having local servers or personal devices to handle the appeal. Cloud refers to a public or semi-public space on transmission lines that exists between the endpoints of a transmission. Data that is transmitted across a WAN enters the network from one endpoint using a standard protocol.