Background And Objectives : Scrub typhus is a chigger-borne zoonotic disease, caused by Orientia tsutsugamushi. Humans are accidental hosts. It occurs all along East Asia with many recent outbreaks in North-East India. It shows similar symptoms to other tropical infections and its disease spectrum ranges from mild febrile illness to severe life-threatening illness with multi organ dysfunctions. This study was done to observe relationship between scrub typhus and liver function. Methods : A hospital based observational study was conducted on randomly selected 40 scrub typhus patients ( between 12 and 60 years) diagnosed by detecting IgM antibody using enzyme linked immunosorbent assay (ELISA) over a period of 1 year at a tertiary care centre, Assam. Liver function tests were performed on the diagnosed cases using reectance spectrophotometry method on automated analyser. The values of LFT were estimated and p-values were calculated to establish statistical signicance. Results : Total 40 number of cases of scrub typhus was taken for our study with a mean age of 29.28 years among which, males were 57.5% and females were 42.5%. Bilirubin elevation was seen in 25 patients (62.5%), AST was increased in 36 patients (90%), ALT was increased in 35 patients (87.5%), ALK was high in 25patients (62.5%), 32 pateints (80%) had hypoalbuminemia, with a p value of < 0.05, which is statistically signicant. Interpretation And Conclusion : Our study concluded that scrub typhus could to be taken into consideration in patients with undifferentiated fever with abnormal liver function tests.
Introduction: A notable feature of patients suffering from mental disorders is the severity of deficiency in the nutrients in diets especially essential vitamins, minerals and omega-3 fatty acids. Iron is a vital nutrient that plays a role in every cell of the body, the deficiency of which will cause depression besides lack of energy, dizziness, light headedness and pale skin.
Aim: The study is aimed to estimate serum iron and Ferritin in adolescent depression cases and to evaluate their role in adolescent depression.
Method material: Patients in the age group of 13 – 19 years, suffering from depression, and attending Psychiatry OPD of Gauhati Medical College are taken as cases. Controls are healthy individuals in the same age group. Samples are collected and serum iron and ferritin are estimated and compared between the two groups. Data are analyzed with the help of Minitab-19 and in MS-excel.
Results: Both serum iron and ferritin are decreased significantly in group containing adolescent with depression. Both are highly significant P<0.001 with ‘t’ values 14.42 and 13.11 respectively.
Conclusion: This Study gives us an idea that while investigating a case of adolescent depression, emphasis must be given to the nutritive status (iron and ferritin) of the individual also.
Background: Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders, occurring in 5–10% women in reproductive ages. Despite a long history of studies on PCOS, its aetiology is still unknown. Oxidative stress is now recognized to play a central role in the pathophysiology of many different disorders, including PCOS. Although intracellular reactive oxygen species (ROS) production and propagation are controlled by highly complex antioxidant enzymatic and non-enzymatic systems, understanding of mechanisms that oxidative stress is important to develop strategies for prevention and treatment of PCOS. Objectives: To estimate the serum levels of superoxide dismutase and uric acid in PCOS patients. Methodology:Acase-control study was conducted in a tertiary care hospital of Assam, with 60 PCOS patients attending the outpatient Department of Obstetrics and Gynaecology, Gauhati Medical College and Hospital (GMCH), Guwahati, Assam along with 60 healthy controls of same age group. The samples were evaluated by ELISA and VITROS 5600 Autoanalyser using standard kits and reagents in the Department of Biochemistry, GMCH. Results: The results were statistically analysed and the mean and SD of SOD were found to be 969.95 + 62.96 among the cases and 1298.8 + 137.8 among the controls with p value <0.001, whereas the mean and SD of uric acid was 5.41 + 0.70 in cases and 3.76 + 0.74 in controls with p value <0.001.Conclusions: Signicantly lower serum levels of SOD and signicantly higher levels of Uric acid were found in cases with PCOS compared to the control group.
Background: Measurement of glycosylated hemoglobin (HbA1c) is considered the gold standard for monitoring chronic glycemic level of diabetes patients. HbA1c is a form of hemoglobin that is measured primarily to identify the average plasma glucose concentration over prolonged periods of time. Levels of HbA1C represent the average blood glucose levels of diabetic patients over the previous 120 days. The objective of this study was to see the correlation between HbA1c levels and glucose levels.
Methods: This cross-sectional study included 60 randomly selected subjects with known diabetes. Both fasting and post prandial blood glucose levels were measured by using venous blood samples. HbA1c levels were measured in venous blood by immunoturbidimetric method. Data were recorded on a proforma in MS-excel sheet. Pearson's coefficient of correlation was applied to find out any significant correlation between the HbA1c levels and the both fasting and postprandial blood glucose levels.
Results: Results were obtained by statistical calculation and plotted with respect to scatter and bar diagram was done and a p<0.05 was considered significant (With 95% CI).
Conclusions: A significant linear positive correlation exists between levels of HbA1C and fasting and post prandial blood glucose.
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