No abstract

The present investigation was carried out to evaluate the ameliorative effect of Andrographis paniculata during E. coli-induced pathology in broilers. Day-old broiler chicks (n = 100) were randomly divided into four equal groups. Group I served as a negative control and was fed with a commercial diet. On day 8, the birds from groups II and IV were challenged with a single oral dose of E. coli broth culture 0.2 mL (1×10 9 cfu/ mL). Groups III and IV were fed with Andrographis paniculata 5 g/kg of feed from day old to the end of the experiment. The total duration of the experiment was 35 days. On the 7 th , 21 st and 28 th day post infection (DPI) with E. coli, six birds from each group were randomly sacrificed and observed for gross and histopathogical observations. Group II birds showed ascites and thickened intestinal mucosa with cheesy material on the 28th and 35th DPI. Pathomorphological alterations, viz. congestion, hemorrhages, degenerations, necrosis, fibrinous exudates, edema, mononuclear cell and heterophil infiltration in the lung, liver, heart, kidneys and duodenum were observed in group II birds, along with depletion of the lymphoid cell population in the spleen. Pretreatment of Andrographis paniculata in the E. coli challenged group led to mild degenerative changes in all organs, indicating the putative protective effect of the plant during E. coli induced pathology in broilers. However, further, more elaborated study is required to calculate the dosage of Andrographis paniculata for use as an antibacterial agent in broiler feed.

A carcass of 10 year old male Sloth Bear (Melursus ursinus) from Maharaj Bag Zoo, Nagpur was brought for a post mortem examination with the history of illness since 15 days and no response to the treatment. The postmortem examination revealed pale mucous membrane, hide bound condition and dehydration. Both the lungs revealed presence of large numbers of caseative nodules of various sizes with enlarged and calcified mediastinal lymphnodes. The impression smears prepared from the caseative nodules of lung showed abundant acid fast tubercular bacilli. Histopathological examination of lungs revealed areas of typical granulomatus reaction with caseasation and aggregation of chronic inflammatory cells and sever thickening of inter alveolar septa due to deposition of fibrin, inflammatory cells, and erythrocytes.

The effects of feeding imidacloprid were assessed in the liver of Japanese quails and studied the effect of feed mix of Butea monosperma on ameliorating effect against the imidacloprid toxicity. The serum biochemical assay revealed significant increase in AST, ALT and GGT in imidacloprid treated birds. Histologically, the liver showed sinusoidal dilatation, bile duct hyperplasia and periportal necrosis. Ultra thin sections of liver revealed numerous fat globules, condensed hepatocytes and mitochondria with granular cytoplasm. It was observed that co-treatment with Butea monosperma moderately restored the imidacloprid induced changes.

No abstract

No abstract

No abstract

No abstract