Aims and Objectives 1. To determine the level of serum cholesterol in patients with major depressive disorder 2. To correlate the serum cholesterol level to the role of pathogenesis in major depressive disorder.
Positron emission tomography (PET) studies suggest increased glucose metabolism in orbital frontal cortex, pre-frontal cortex and anterior cingulate gyrus, right caudate nucleus. Neuroanatomical factors Neuroimaging studies that have been implicated the frontal-basal ganglio thalamic cortical circuit in the pathogenesis of the disorder. Neurochemical basis Oxidative stress causes neuronal damage in the above mentioned areas. Damage caused disturbs intracellular events resulting in impaired release of neurotransmitters like serotonin, dopamine which have been
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