This review provides an overview of the progress made by computational and systems biologists in characterizing different cell death regulatory mechanisms that constitute the cell death network. We define the cell death network as a comprehensive decision-making mechanism that controls multiple death execution molecular circuits. This network involves multiple feedback and feed-forward loops and crosstalk among different cell death-regulating pathways. While substantial progress has been made in characterizing individual cell death execution pathways, the cell death decision network is poorly defined and understood. Certainly, understanding the dynamic behavior of such complex regulatory mechanisms can be only achieved by applying mathematical modeling and system-oriented approaches. Here, we provide an overview of mathematical models that have been developed to characterize different cell death mechanisms and intend to identify future research directions in this field.

Over the past few decades, technological advances in endodontics have taken quantum leaps from conventional hand files to rotary system and from direct vision to magnification. The clarity and details are achieved by magnification devices such as orascope, dental loupes, and dental operating microscope. The details are very clear and revealing so that the endodontists can achieve precision in diagnosis, treatment procedures, and final assessment of procedure performed. Magnification technique is undergoing continuous advancements, allowing a better precision and quality standard. Microdentistry with its expanding possibility and increased clinical implication has now set a higher standard in patient care and in success rate of treatment procedures.