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Objectives-To investigate acute effects of intra-amygdalar excitatory amino acid administration on blood flow, relaxation time and apparent diffusion coefficient in rat brain.Materials and Methods-Several days after MR-compatible cannula placement in right basolateral amygdala, anesthetized rats were imaged at 7T. Relative CBF was measured before and 60 minutes after infusion of 10 nanomoles KA, cAMPA, ATPA, or normal saline using arterial spin labeling. Quantitative T 2 and diffusion weighted images were acquired. rCBF, T 2 and ADC values were evaluated in bilateral basolateral amygdala, hippocampus, basal ganglia, frontal and parietal regions.Results-KA led to the highest, and ATPA lowest bilateral rCBF increases. Time courses varied among drugs. T 2 for KA and AMPA was higher while ADC was lower for KA.Conclusions-Intraamygdalar injection of GluR agonists evoked bilateral seizure activity and increased rCBF, greater for KA and AMPA than selective ATPA GluR5 activation.

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