Cancer subtypes identification is one of the critical steps toward advancing personalized anti-cancerous therapies. Accumulation of a massive amount of multi-platform omics data measured across the same set of samples provides an opportunity to look into this deadly disease from several views simultaneously. Few integrative clustering approaches are developed to capture shared information from all the views to identify cancer subtypes. However, they have certain limitations. The challenge here is identifying the most relevant feature space from each omic view and systematically integrating them. Both the steps should lead toward a global clustering solution with biological significance. In this respect, a novel multi-omics clustering algorithm named RISynG (Recursive Integration of Synergised Graph-representations) is presented in this study. RISynG represents each omic view as two representation matrices that are Gramian and Laplacian. A parameterised combination function is defined to obtain a synergy matrix from these representation matrices. Then a recursive multi-kernel approach is applied to integrate the most relevant, shared, and complementary information captured via the respective synergy matrices. At last, clustering is applied to the integrated subspace. RISynG is benchmarked on five multi-omics cancer datasets taken from The Cancer Genome Atlas. The experimental results demonstrate RISynG’s efficiency over the other approaches in this domain.
Introduction: Cervical ectopic pregnancy is a rare life threatening condition that implants in the endocervical lining, accounting for less than 1% of all ectopics. Aim: Successful diagnosis, management and challenges of cervical pregnancy. Study Design: A case series on 5 cases of cervical pregnancy in SRMC, Chennai, their timely diagnosis, associated risk factors (previous surgeries, ART) and management modalities -foleys tamponade, Multi dose methotrexate regimen, suction and evaluation with or without UAE. Results: The mean gestational age of diagnosis was seven weeks. The median serum human chorionic gonadotropin level was 11 300 IU/L (range 610 to 163 700). Fetal cardiac activity was present in 1 case. Vaginal bleeding was the most common presentation. All cases were successfully managed conservatively, thus allowing uterine preservation. Systemic methotrexate (multi-dose protocol) was the mainstay of therapy. Other minimally invasive interventions included ultrasound-guided injection of potassium chloride into the pregnancy, uterine artery embolization, and dilatation and curettage, with Foley catheter tamponade. Conclusion: Cervical pregnancy has become not so rare now with risk factors like high caesarian rate and ART. Hence, timely diagnosis by ultrasound and effective management reduces the risk of severe life threatening hemorrhage or hysterectomy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.