Syntheses of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) were evaluated with an emphasis on controlling the size, shape and stability of nanoparticles (NPs). Various reducing and capping agents of NPs from the sphere of chemistry and biology were identified together with their role in synthesis and controlled NPs properties. Those NPs were characterized with a variety of methods in order to determine the activities of nanoparticles and their applications in real life. In addition, carriers of these NPs in-vitro and in-vivo investigations and models of nanoscale interactions are presented. This review also addresses systematically the biomedical applications of AuNPs and AgNPs taking into account the actual challenges and perspectives in this research field.
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