Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.

Abstract:We explore seasonal variability and spatiotemporal patterns in characteristic drainage timescale (K) estimated from river discharge records across the Kilombero Valley in central Tanzania. K values were determined using streamflow recession analysis with a Brutsaert-Nieber solution to the linearized Boussinesq equation. Estimated K values were variable, comparing between wet and dry seasons for the relatively small catchments draining upland positions. For the larger catchments draining through valley bottoms, K values were typically longer and more consistent across seasons. Variations in K were compared with long-term averaged, Moderate-resolution Imaging Spectroradiometer-derived monthly evapotranspiration. Although the variations in K were potentially related to evapotranspiration, the influence of data quality and analysis procedure could not be discounted. As such, even though recession analysis offers a potential approach to explore aquifer release timescales and thereby gain insight to a region's hydrology to inform water resources management, care must be taken when interpreting spatiotemporal shifts in K in connection with process representation in regions like the Kilombero Valley.

Evapotranspiration (ET) plays a crucial role in integrated water resources planning, development and management, especially in tropical and arid regions. Determining ET is not straightforward due to the heterogeneity and complexity found in real-world hydrological basins. This situation is often compounded in regions with limited hydro-meteorological data that are facing rapid development of irrigated agriculture. Remote sensing (RS) techniques have proven useful in this regard. In this study, we compared the daily actual ET estimates derived from 3 remotely-sensed surface energy balance (SEB) models, namely, the Surface Energy Balance Algorithm for Land (SEBAL) model, the Operational Simplified Surface Energy Balance (SSEBop) model, and the Simplified Surface Balance Index (S-SEBI) model. These products were generated using the Moderate Resolution Imaging Spectroradiometer (MODIS) satellite imagery for a total of 44 satellite overpasses in 2005, 2010, and 2015 in the heterogeneous, highly-utilized, rapidly-developing and data-limited Kilombero Valley (KV) river basin in Tanzania, eastern Africa. Our results revealed that the SEBAL model had a relatively high ET compared to other models and the SSEBop model had relatively low ET compared to the other models. In addition, we found that the S-SEBI model had a statistically similar ET as the ensemble mean of all models. Further comparison of SEB models’ ET estimates across different land cover classes and different spatial scales revealed that almost all models’ ET estimates were statistically comparable (based on the Wilcoxon’s test and the Levene’s test at a 95% confidence level), which implies fidelity between and reliability of the ET estimates. Moreover, all SEB models managed to capture the two spatially-distinct ET regimes in KV: the stable/permanent ET regime on the mountainous parts of the KV and the seasonally varied ET over the floodplain which contains a Ramsar site (Kilombero Valley Floodplain). Our results have the potential to be used in hydrological modelling to explore and develop integrated water resources management in the valley. We believe that our approach can be applied elsewhere in the world especially where observed meteorological variables are limited.

No abstract