Background: PKC␦ signaling to mitochondria affects cellular apoptosis and metabolism. Results: A structure-function study using FRET-based imaging reveals that PKC␦ binds to and is active at mitochondria via multiple isozyme-specific determinants. Conclusion: Determinants unique to PKC␦ drive an interaction with mitochondria distinct from canonical PKC translocation to membranes. Significance: Isozyme-specific interaction of PKC␦ with mitochondria constitutes a novel recruitment mechanism and increases mitochondrial respiration.
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