Optimizing patients’ condition before liver transplantation (LT) could potentially improve survival of LT patients. We focused on sarcopenia, as a common factor in liver transplant candidates that can impact their cardiopulmonary performance at the point of listing, morbidity, and mortality after LT. We performed a single-center cohort study on 98 consecutive patients with liver cirrhosis who were transplanted between March 2015 and December 2017. The third lumbar vertebra skeletal muscle index (L3SMI) was calculated using CT imaging to distinguish sarcopenia at listing for LT. Data regarding liver function, body mass index (BMI), cardiac biomarkers, the peak oxygen uptake (VO2) and LT outcome were collected and correlated to L3SMI. For data analysis the Dell Statistica (Version 13. Dell Inc., Rondrock, TX, USA) was used. In total, 98 cirrhotic patients were included. Fifty-five (56.1%) patients, mostly males, had sarcopenia according to L3SMI, with the lowest L3SMI in males with alcohol-related liver disease. Lower L3SMI correlated with lower BMI, lower VO2 peak, and higher NTproBNP (all p < 0.001) and revealed an essential correlation with prolonged ICU stay (r = −0.21, p < 0.05). 33 patients were unable to perform cardio-pulmonary exercise test, mostly sarcopenic (67%), with more advanced liver insufficiency (assessed with CPC and MELD scores) and longer stay at ICU after LT (all p < 0.001). Sarcopenia was common among LT recipients. It was associated with inferior result in cardio-pulmonary performance before LT and prolonged ICU stay after grafting.
In June 2009 the World Health Organization announced influenza pandemic caused by A/H1N1/v virus. It became crucial to recognize new cases of A/H1N1/v infection. An effective screening diagnostic procedure was needed for patients suffering from influenza-like symptoms for making an initial diagnosis and analyzing epidemiological pattern of infection. We used a strip test for influenza A/B as a screening diagnostic procedure for patients suffering from influenza-like symptoms for making an initial diagnosis. For comparison, RT PCR for detecting A/H1N1/v was performed. The aim of this study was to assess the efficacy and sensitivity of the strip test and its value for making initial diagnosis of influenza A/H1N1/v. Strip testing for the influenza A/B infection was performed on 1123 patients with influenza-like symptoms in the Admission Unit of the Regional Infectious Diseases Hospital in Warsaw. Strip test results were analyzed according to the age of patients and season of the year. For 97 patients strip test results for detecting A/H1N1 infection were compared with those obtained by RT PCR. There were no statistically significant differences found between the methods and strip testing demonstrated sensitivity of 61% and specificity of 71%. No statistically significant differences were found between the two methods, however, strip test had low sensitivity and specificity.
for malignancies 2 or small -for -size syndrome in the recipients of living -donor grafts. 3 However, a smaller liver volume (LV) is observed in advanced liver cirrhosis with an increasing Child-Pugh class (CPC). 1,4-6 Additionally, according to Ozaki et al, 1 morphometric differences between etiologies would decrease with progression of cirrhosis. In individuals with cirrhosis and portal hypertension, only a 75% LV is expected compared with age -matched controls. 7 Changes in LV over time were suggested to be an indicator of therapeutic effectiveness or liver disease progression. 8 The advent of novel direct antiviral agents (DAAs), with a 90% efficacy of sustained viral IntroductIon Liver cirrhosis is characterized by several alterations affecting the hepatic tissue: fibrotic deposits involving the centrilobular vein, perisinusoidal space, and portal triad; active hepatocellular hyperplasia; and nodular formation with disruption of the normal microvascular architecture of the hepatic sinusoids, leading to progressive derangement of the liver morphology and function. However, Ozaki et al 1 noted numerous morphometric changes in liver modeling across various etiologies of cirrhosis.Liver volumetry is a method used to assess the risk of inducing liver failure in candidates for liver resection prior to hepatectomy
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