The presence of an antibody with specificity against streptomycin-sensitized red blood cells in the serum of a patient with tuberculous pericarditis is reported. Hemolysis and significant anemia were absent. The antibody appeared to develop together with an evolving warm autoantibody, but was clearly separable from the latter. The streptomycin-specific antibody was "penicillin-like" by being totally neutralized in the presence of streptomycin. Red blood cells had to be separately sensitized with streptomycin prior to incubation with the antibody. The antibody cross-reacted with neomycin-sensitized cells and was also neutralized by the presence of neomycin. In addition, a possible cross-reactivity of the streptomycin-specific antibody and the warm autoantibody is suggested. The association of a drug-induced antibody and autoimmune antibody of IgG type is most unusual. In our experience, we have encountered only one similar example.
Typing for antigens in the Dombrock blood group system and identifying the corresponding antibodies are notoriously difficult tasks. The reagents are scarce and the antibodies are weakly reactive. When RBCs from family members of a patient with an antibody to a high-prevalence Dombrock antigen were tested for compatibility, an unusual pattern of inheritance was observed: RBCs from the patient's children and one niece, in addition to those from some of the patient's siblings, were compatible. This prompted the performance of DNA-based assays for DO alleles and the results obtained were consistent with and explained the compatibility test results. It was possible to study this large kindred because of the cooperation of family members, hospital personnel, and reference laboratory staff.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.