Neurodegeneration associated with pantothenate kinase deficiency is a rare disease. To confirm its diagnosis, studies are needed that are often not available in all countries and times (as in this case). Clinical case: In the Child Psychiatry ward of the "Juan Manuel Márquez" Pediatric Hospital, an adolescent was treated with psychiatric disorders of psychotic functioning level with little response to treatment, extrapyramidal manifestations and other progressive neurological dysfunction. The classic image of "tiger eyes" was evidenced by magnetic resonance imaging of the skull, at the beginning unilateral, and at 10 months it was performed again, verifying the bilateral image, in addition to significant cognitive, language, communication and loss of skills deterioration. With regression, affective symptoms and sleep disorder. Conclusions: Although neurodegeneration associated with pantothenate kinase deficiency is a rare disease and in the present case it could only be considered probable, it should be included in the differential diagnosis of children and adolescents with the progression of clinical manifestations, including extrapyramidal dysfunction. dementia, even in the absence of a tiger-eye image at the onset of manifestations or its unilateral presence. Psychiatric manifestations were the cause of admission from the start, and their persistence and poor response to treatment may be a manifestation that alerts to the presence of this disease.
To know the evolution, according to the pharmacological treatment received, of the patients admitted to the Psychiatric Ward of the "Juan Manuel Márquez" Paediatric Hospital, with Bipolar Disorder (TB) in the period from January 2009 to December 2011, the present study. The objective is to identify the evolution of the patients three, six and twelve months after hospital discharge according to the pharmacological treatment used. A retrospective longitudinal descriptive study was carried out between May 2012 and May 2013. 81 hospitalized patients with TB were studied. The source of information was their medical records and a semi-structured interview. The data was processed in SPSS version 15 and the results are presented in statistical tables. Three months after hospital discharge, the highest percentage of patients with satisfactory clinical status had treatment with Haloperidol alone, in second place Risperdal and Carbamazepine and in third place the combination of Haloperidol and Magnesium Valproate (Mg), while Six months was Haloperidol alone, followed by the combination of Olanzapine and Lithium Carbonate, Risperdal and Mg Valproate, one year after hospital discharge the combination of Olanzapine and Lithium Carbonate was found first, followed by Risperdal with Carbamazepine and of quetiapine alone. The treatments most associated with satisfactory clinical status were: Haloperidol alone, Quetiapine alone, as well as the combinations of Risperdal and Carbamazepine, Risperdal and Mg Valproate, Olanzapine and Lithium Carbonate, and Haloperidol with Mg Valproate.
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