The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield.
STM brings to light chirality aspects of the self-assembly of a functionalized helicene at the interface between a liquid and the solid substrates, gold and graphite. This reveals conditions for conglomerate formation.
A combination of Scanning Tunnelling Microscopy and Density Functional Theory simulations highlights the role of van der Waals interactions in the self-assembly of an aminohelicene on Cu(100) and Au(111).
A facile and efficient resolution of omeprazole as the monopotassium salt diethanol solvate using coupled preferential crystallization has been developed. This approach uses small perturbations in solution-phase concentration to control the competing process of selective crystal growth while suppressing unwanted primary nucleation. The result is a selective crystallization technique that replaces the traditional batch-type isolation with a continuous process amenable to scale, which provides easy access to enantiopure conglomerate crystals.
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