A new modular building system for the combinatorial chemistry was developed on the basis of triazene linkers. Starting from an aniline system, further functional units and virtually any alkene or alkyne as terminator furnished lipophilic multicomponent systems in high yields and purities without the need for purification steps (see schematic representation).
Up to nine C-C bonds are formed selectively from up to seven components starting from an alkene, a haloarene, and a dienophile [Eq. (1)]. A comparison of liquid- and solid-phase reactions reveals a surprising superiority of the solid-phase reaction.
Bis zu neun C‐C‐Bindungen werden selektiv aus bis zu sieben Komponenten geknüpft, ausgehend von einem Alken, einem Halogenaren und einem Dienophil [siehe Gl. (1)]. Ein Vergleich von Flüssig‐ und Festphasenreaktionen ergab eine erstaunliche Überlegenheit der Festphasenreaktion bei der Reaktionsführung.
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