Testosterone exposure caused an increase in cell proliferation for CS osteoblast cells. However, a therapy targeted to mitigate this response (flutamide therapy) similarly affected CS and WT cells, suggesting that the administration of flutamide or TP in the presence of flutamide decreases osteogenesis of these cells. Thus, although our data support a mechanism of gene-environmental interaction, these results would not support a therapeutic intervention based on this interaction.
Background: Restoration of the complex three-dimensional form of the mid-face in patients with extensive craniofacial defects is one of the most challenging reconstructive surgeries. Our goal was to improve the accuracy of our reconstructions using virtual planning, rapid prototype modeling, and stereotactic navigation.
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