The present research investigated whether the outbreak of COVID-19 would increase Chinese participants’ tendency of seeing meaning in negative experiences (MINE). A longitudinal study (Study 1, N = 2535) showed that Chinese college students reported higher tendency of MINE during the outbreak of COVID-19 than three months before the outbreak. A cross-sectional study (Study 2) investigated a large student sample (N = 16096) and a large non-student sample (N = 11446) during the outbreak of COVID-19 in China and consistently showed that participants who were encountering high disease threat reported stronger perceived threat as well as greater tendency of MINE than those who were encountering low disease theat. Furthermore, the heightened perception of threat accounted for the heightened tendency of MINE. These results suggest that the COVID-19 outbreak makes Chinese more likely to see meaning in negative experiences, which may provide benefits for coping.
Introduction: The present study focuses on the interaction between long non-coding RNA GAS5 and microRNA-205-5p and their roles in cisplatin-induced acute kidney injury. Methods: Human kidney tubular cells (HK-2) were used to simulate acute renal injury induced by cisplatin with the consequent fluctuating expression levels of GAS5 and MIR-205-5p being determined respectively. Furthermore, the modulating effects of miR-205-5p and GAS5 in cisplatin-induced apoptosis of renal tubular epithelial cells and the possible binding sites between them were evaluated. Results: The results depicted that the expression of GAS5 was significantly up-regulated after AKI induced by cisplatin, while inhibiting the increase of expression would alleviate the apoptotic-promoting effect of cisplatin on renal tubular epithelial cells. MIR-205-5p is negatively regulated by GAS5, thus down-regulation of GAS5 will consequently elevate the expression of miR-205-5p and further alleviate the damage of HK-2 cells induced by cisplatin. Conclusions: In conclusion, in cisplatin-induced AKI, the expression of GAS5 was increased and consequently inhibited that of miR-205-5p by direct binding, which eventually aggravate the renal tubular epithelial injury, indicating their potential of being important diagnostic markers and therapeutic targets in the treatment of cisplatin-induced AKI.
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