In this article, the qualitative indicators of yarn obtained from cotton fiber stored in a bundle of small sizes and volume were considered in order to determine its quality by processing the results of a full factorial experiment. Attention was also paid to the time spent on the experiment and the equipment used. Based on this and assuming the presence of a paired influence between the factors, the central compositional rototable planning of the experiment of the second order was adopted. The experimental study was planned to be carried out in two stages. A full-factorial experimental study was carried out on a small-sized spinning machine “Shirley” JSC “Scientific Center Pakhtasanoat” and yarn T-19.5 tex was produced. To determine the physical and mechanical properties of the threads, modern equipment of the testing laboratory “CentexUz” at TITLI was used. The results of a full-factorial experiment on the production of yarn from cotton fibers in a bundle of small sizes or volume are shown in tables 1-5, based on the results of the experiment, regression coefficients were found and equations were drawn up. According to the results, the threads of the 6th variant in terms of indicators were recognized as the best option.