To determine whether myogenic factors are responsible for slowed colonic transit in senescent rats, maximum shortening velocity (V0), compliance of the series elastic component (SEC), measurements of passive force in calcium‐depleted tissue and peak isometric force (F0) were examined in proximal and distal colonic circular smooth muscle from 6‐ and 30‐monthold Fischer rats (n = 5). After mucosa was removed, measurements were made on strips stimulated with 80 m>m KCl in a 2.5 m>m Ca2+ Kreb's solution. Muscle strips were quick released at peak isometric force (F0) to afterloads of 60% of F0. The changes in muscle length from zero to 40 msec and 1 to 2 sec after release during isotonic contraction were used to calculate the SEC and V0 as a fraction of total muscle length. Passive force (Fp) was measured in 2.5 m>m Ca2+ Kreb's solution and in a zero Ca2+, 0.1 m>m EGTA solution to determine the contribution of contractile and passive elements to passive force. The results of these studies indicate there is no difference in the V0 (L0/sec) of adult (8.4 ± 1.5) and aged (7.5 ± 2.0) animals (P ± 0.05). Peak force (F0) in the distal colon of the aged rats was greater than adult rats (1.23 ± 0.1 vs 0.85 ± 0.01 kg/cm2, P = 0.05). The stiffness of the parallel elastic component and the length‐tension relationship were similar in adult and aged animals. Negligible decreases in Fp were observed in zero calcium medium. However, basal contractile tone was elevated in aged animals (P = 0.05). These studies indicate basic differences in aged colonic circular muscle that may contribute to altered bowel transit and function during ageing.
Psoriasis patient self-interpretation of outcomes may be utilized to develop Population-Based Care (defined as systems that use data derived from large patient populations to guide the care of individuals) and identify Social Determinants of Health (SDOH), defined as non-medical factors influencing disease risk. Patients with psoriasis recognize that disease manifestations and outcomes are modified by many factors e some inherent and others effected by patients and their environment. Many patients feel these factors are not given enough time or attention during healthcare interactions and use social media to excess concerns including dissatisfaction with their doctor's ability to meet emotional and informational needs; keeping up with latest breakthroughs; eradicating the gap in health information about their condition and everyday life; and commiserating/networking with other psoriasis patients. To address the feasibility of programming supercomputers to interpret the millions of publicly available social media posts concerning patient-oriented views on outcomes, a qualitative Facebook analysis of 100 public psoriasis-related posts was conducted. These posts were grouped into one or more categories based on the patients' concerns. The focus of the posts was on sharing personal experiences (n¼47); seeking advice/treatment (n¼40); seeking information about psoriasis and/or related medications (n¼25); seeking emotional support and/or inspiring others (n¼24); giving advice/recommendations (n¼14); and discussing adverse side effects (n¼12). This analysis will serve as a framework from which to program supercomputers to interpret the high volume of information regarding psoriasis on social media. This system can ultimately be used to identify and incorporate SDOH into care management systems as well as drive Population-Based Care to help provide proactive, evidence-based interventions and coordinated care, ultimately improving clinical outcomes at lower costs. 599Impact of atopic dermatitis on overall health-related quality of life and health utility scores in US adult patients BT Cheng and J Silverberg Northwestern University, Chicago, Illinois, United States Previous studies showed atopic dermatitis (AD) is associated with significant burden and decrease in quality of life (QOL). However, the impact of AD on health utility scores and overall QOL in US adults is not well-understood. This study analyzed the 2002-2015 Medical Expenditure Panel Survey, a representative survey of US health expenditures and utilization, to examine the effect of AD diagnosis (weighted frequency¼438,920 adults) on health utility scores and compare with other chronic conditions. Diagnoses were identified using ICD9 codes. Short form (SF)-12 was assessed; mental and physical component scores (MCS and PCS) and SF-6D healthy utility scores were estimated. Persons with AD vs non-AD controls had decreased SF-6D health utility scores (mean [95% CI]: 0.48 [0.45-0.52] vs 0.62 [0.62-0.63], respectively; P<.0001), lower vs 50.2 [50.1-50.3]; P¼0.03), ...
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