Our study demonstrated that copper inhibited osteogenic differentiation of rBMSCs in vitro. The findings caution appropriate use of copper and have laid a foundation for further research.
Gastroesophageal reflux disease (GERD) may be a potential risk factor for exacerbations of chronic obstructive pulmonary disease (COPD). The aim of the present study was to explore the association of GERD risk with exacerbations of COPD. Patients with COPD were consecutively recruited, and COPD Assessment Test (CAT) and Reflux Diagnostic Questionnaire (RDQ) were administered. If the CAT score was 5 points higher than that taken in the stable states, the patient was considered as having exacerbations of COPD. A RDQ score of ≥ 12 is defined high GERD risk. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between high GERD risk and exacerbations of COPD. Among 386 patients with COPD, the mean CAT score was 18.3 ± 6.6, and 76 (19.7%) patients had exacerbations during the 1-year follow-up. The mean RDQ score was 10.1 ± 4.7, and 132 (34.2%) patients were identified as having high GERD risk. Multivariate logistic regression analyses revealed that the high GERD risk (odds ratio, 2.31; 95% confidence interval, 1.29-3.87) was an independent risk factor of COPD exacerbations. In conclusion, high GERD risk appears to be associated with higher odds for COPD exacerbations.
Objectives: Bariatric surgery has been recommended as an effective treatment for overweight or obese patients with type 2 diabetes mellitus. The long-term follow up of such patients, however, has been limited. We performed a systematic review and meta-analyses to evaluate the long-term effect of bariatric surgery on patients with type 2 diabetes. MethOds: We searched PubMed, EMbase, and Cochrane Central Register of Controlled Trials up to September 2013. Trained reviewers, working in pairs, independently screened for eligible studies and extracted data. We pooled the data by using random-effects meta-analysis; qualitative description was applied for the data not available for pooling. We conducted pre-specified subgroup analyses. Results: We included 25 studies (n= 23,628), consisting of 8 cohort studies with 17407 patients (moderate or high risk of bias) and 17 non-controlled follow up studies with 6221 patients (high risk of bias). At baseline, the mean age of 48.5 years (69% were female), mean body mass index (BMI) was 45 kg/m 2 , 67% of patients received oral antidiabetic drug prior to surgery. 2.6% of patients (130/4950) died in the surgical group. Improvement on cardiovascular complications, nephropathy and quality of life was observed. BMI (-13.13 kg/m 2 [-17.66,-9.07]), Fasting Plasma Glucose (-59.74 mg/dl [-74.59,-44.89]), and hemoglobin A1c (-1.83% [-2.4,-1.25]) declined significantly postoperatively. 67.1% of patients were in remission; diabetes was improved or resolved in 89.2% of patients. Subgroup analysis for alterative surgical procedures, length of follow up and the methods of data collection suggested no significant different. cOnclusiOns: Bariatric surgery should be considered as a long-lasting and effective treatment for patients with type 2 diabetes. However, our results are based on a small number studies with low quality, additional carefully designed studies on mortality, cardiovascular events and adverse events may provide further clarification. PDB11
Objectives: Bariatric surgery has been recommended as an effective treatment for overweight or obese patients with type 2 diabetes mellitus. The long-term follow up of such patients, however, has been limited. We performed a systematic review and meta-analyses to evaluate the long-term effect of bariatric surgery on patients with type 2 diabetes. MethOds: We searched PubMed, EMbase, and Cochrane Central Register of Controlled Trials up to September 2013. Trained reviewers, working in pairs, independently screened for eligible studies and extracted data. We pooled the data by using random-effects meta-analysis; qualitative description was applied for the data not available for pooling. We conducted pre-specified subgroup analyses. Results: We included 25 studies (n= 23,628), consisting of 8 cohort studies with 17407 patients (moderate or high risk of bias) and 17 non-controlled follow up studies with 6221 patients (high risk of bias). At baseline, the mean age of 48.5 years (69% were female), mean body mass index (BMI) was 45 kg/m 2 , 67% of patients received oral antidiabetic drug prior to surgery. 2.6% of patients (130/4950) died in the surgical group. Improvement on cardiovascular complications, nephropathy and quality of life was observed. BMI (-13.13 kg/m 2 [-17.66,-9.07]), Fasting Plasma Glucose (-59.74 mg/dl [-74.59,-44.89]), and hemoglobin A1c (-1.83% [-2.4,-1.25]) declined significantly postoperatively. 67.1% of patients were in remission; diabetes was improved or resolved in 89.2% of patients. Subgroup analysis for alterative surgical procedures, length of follow up and the methods of data collection suggested no significant different. cOnclusiOns: Bariatric surgery should be considered as a long-lasting and effective treatment for patients with type 2 diabetes. However, our results are based on a small number studies with low quality, additional carefully designed studies on mortality, cardiovascular events and adverse events may provide further clarification. PDB11
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