Deboleza is a behavioural construct among the inhabitants of Istria (a peninsula in the Adriatic Sea which belongs mainly to Croatia); it has peculiar social, ethno-psychological and historical characteristics because it is a relatively small region which has been the intersection of various cultures and civilizations. In this research the concept is analysed from the psychomedical point of view. As deboleza does not have the status of an illness, it functions as a culture-bound syndrome which, because of its emotional expressions, belongs to the ‘shame’ family. This interesting construct should be thoroughly studied not only in a peculiar and dynamic Croatian culture and in Croatian psychiatry, but also within European culture and psychiatry.
Aims: CYP2C19 transgenic mouse expresses the human CYP2C19 gene in the liver and developing brain, and it exhibits altered neurodevelopment associated with impairments in emotionality and locomotion. Because the validation of new animal models is essential for the understanding of the aetiology and pathophysiology of movement disorders, the objective was to characterise motoric phenotype in CYP2C19 transgenic mice and to investigate its validity as a new animal model of ataxia.
Methods:The rotarod, paw-print and beam-walking tests were utilised to characterise the motoric phenotype. The volumes of 20 brain regions in CYP2C19 transgenic and wild-type mice were quantified by 9.4T gadolinium-enhanced post-mortem structural neuroimaging. Antioxidative enzymatic activity was quantified biochemically. Dopaminergic alterations were characterised by chromatographic quantification of concentrations of dopamine and its metabolites and by subsequent immunohistochemical analyses. The beam-walking test was repeated after the treatment with dopamine receptor antagonists ecopipam and raclopride.
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