A novel synthesis of 3‐(hydroxymethyl)chromones from o‐hydroxy‐ω‐(methylsulfinyl)acetophenones has been developed. These have been utilized in the synthesis of 3‐formyl, 3‐cyano, 3‐carboxy, 3‐carboxamido, 3‐chloromethyl, 3‐aminomethyl and 3‐methoxymethylchromones.
An antifungal antibiotic, 5-epi-5,6-dihydroxypolyangioic acid (1), has been isolated from Polyangium celluosum var. fulvum and its structure elucidated by a comparison of the NMR spectra of diacetates 3 and 6, and by conversion of 5,6-dihydroxypolyangioic acid (4) into 1.
Sir:1 his communication is the first of a series concerned with the synthetic uses of ortho-substituted 0-ketosulfoxides. In particular, it deals with new syntheses of chromones, flavones, thioflavones and thioindigo.Extension of our work on the addition of dimethyl-
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