We studied the status of proliferation processes (by Ki-67 expression) and biogenesis of free radicals (by chemiluminescence method) in skin biopsy specimens from patients with atopic dermatitis and lichen planus. The index of Ki-67-positive nuclei significantly (p<0.05) increased to 28.40±2.00% in patients with dermatitis and to 32.6±1.9% in patients with lichen planus vs. 8.65±1.31% in the reference sample. Decompensated accumulation of free-radical oxidation products and inhibition of detoxification systems in skin biopsy specimens indicate the development of local oxidative stress. After therapy consisting of two 10-day courses of thymodepressin injections (0.1%, 1.0 ml) over 30 days, normalization of epidermis proliferation was observed. Labeling index in atopic dermatitis and lichen planus significantly decreased (p<0.05) to 17.00±1.87 and 10.9±1.1%, respectively. The role of free radicals in the development of hyperregeneratory processes during dermatoses is discussed.
Acne is the most common skin disorder, affecting almost 90 % of young people under the age of 20. Modern research also indicates an increase in the incidence in adulthood. According to Russian and foreign literature, the incidence of acne in women aged 25–55 years ranges from 3 to 40 % Moreover, in recent years, more often in women, the onset of acne occurs at the age of over 25 years. Localization of rashes on the face, considered by women as a cosmetic defect, in almost all patients leads to the formation of various psychoemotional disorders, causes difficulties in social and professional adaptation, while in adult women these disorders are more pronounced than at puberty. The article discusses the etiopathogenesis and therapy of late acne and their consequences in women. The results of studies of the effectiveness of methods of treating late acne in women, depending on the factors of their occurrence, are presented, the use of hormone replacement therapy is substantiated. The authors have shown the high efficiency and compliance of the combination therapy of late acne in women
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