A method for peri annulation of the pyridine or pyran ring to acridine was developed and used to obtain 7H pyrido and 7H pyrano[2,3,4 kl]acridin 2(3H) ones. The peri groups were formed by a reaction of 9 chloro 1 nitroacridine with a CH acid (malononitrile, ethyl cyanoacetate, and ethyl malonate) followed by reduction of the nitro group, or by a reaction of 1 amino 10 methylacridone with PCl 5 and then with a CH acid. Replacement of the chlorine atom in 9 chloro 1 methoxyacridines by the residue of the CH acid with subsequent heating in an acidic medium afforded 7H pyrano[2,3,4 kl]acridin 2(3H) ones, which belong to a novel heterocyclic system.
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