The paper studies features of clinical manifestation of acute gastroenteritis with different (rotavirus, adenovirus, and astrovirus) etiology in children in Uzbekistan. Totally 1050 children of age 6-59 months hospitalized with acute gastroenteritis were enrolled into study. Viral etiology was determined in 67.5% of cases. Rotavirus differs from the adenoviral infection with acute onset, severe feverish reaction, repeated vomiting, more frequent and severe intoxication and character of diarrhea. Clinical manifestation of adenovirus differs from rotavirus and adenovirus with subacute onset, lower frequency of vomiting, more frequent development of exsicosis degree I and II, expressed by abdominal pain and flatulence. Astrovirus infection is characterized by acute onset, frequent, repeated, profuse vomiting on background of subfebrile temperature and watery diarrhea. Duration of clinical signs of diarrhea is greater at adenovirus.
Известно, что темпы формирования цирроза печени (ЦП) у больных х роническим гепатитом В обусловлены скоростью прогрессии фиброза, связанной с выраженностью воспалительных изменений в ткани печени. С нарастанием длительности болезни тяжесть заболевания увеличивается. По лабораторным показателям трудно судить о тяжести болезни. Не было прямой связи между тяжестью болезни и вирусной нагрузкой. Наибольшие проблемы возникают при постановке диагноза в начальной стадии ЦП или в переходном периоде хронического вирусного гепатита в ЦП.
Objective. To evaluate the role of dynamics of WFA+-M2BP, a serum marker of liver fibrosis, in patients with chronic hepatitis C (CHC). Patients and methods. We examined 56 CHC patients who received antiviral therapy. The severity of liver fibrosis was assessed using indirect elastometry. There were 8 patients with F0 fibrosis, 17 patients with F1 fibrosis, 6 patients with F2 fibrosis, 12 patients with F3 fibrosis, and 13 patients with F4 fibrosis. The level of WFA+-M2BP was measured prior to treatment initiation, then 1 month after treatment initiation, and 3 months after treatment completion. Results. We found that both CHC patients and patients with HCV-induced liver cirrhosis demonstrated a decrease in the serum level of WFA+-M2BP in response to antiviral therapy. Mean levels of WFA+-M2BP in individuals with F3 and F4 fibrosis were significantly higher than those in patients with F0 fibrosis (p < 0.01). Conclusion. Higher grades of liver cirrhosis were associated with higher serum levels of WFA+-M2BP, while antiviral therapy led to a decrease in the concentration of this biomarker. The assessment of WFA+-M2BP dynamics will help to detect early stages of liver fibrosis and also to monitor it in patients receiving antiviral therapy. Key words: chronic hepatitis C, liver cirrhosis caused by HCV, biomarker, WFA+-M2BP, liver fibrosis, antiviral therapy
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