Short-term adverse events are common following the BNT162b2 vaccine for SARS-Cov-2 and have been possibly associated with IgG response. We aimed to determine the incidence of adverse reactions to the vaccine and the impact on IgG response. Our study included 4156 health-care professionals who received two doses of the BNT162b2 vaccine 21 days apart and obtained 6113 online questionnaires inquiring about adverse events. The serum response was tested in 2765 subjects 10 days after the second dose. Adverse events, most frequently a local reaction at the site of injection, were reported by 39% of subjects. Multivariate analysis showed that female sex (odds ratio—OR—1.95; 95% confidence interval—CI—1.74–2.19; p < 0.001), younger age (OR 0.98 per year, p < 0.001), second dose of vaccine (OR 1.36, p < 0.001), and previous COVID-19 infection (OR 1.41, p < 0.001) were independently associated with adverse events. IgG response was significantly higher in subjects with adverse events (1110 AU/mL—IQR 345-1630 vs. 386 AU/mL, IQR 261-1350, p < 0.0001), and the association was more pronounced in subjects experiencing myalgia, fever, and lymphadenopathy. We demonstrate that a more pronounced IgG response is associated with specific adverse events, and these are commonly reported by health care professionals after the BNT162b2 vaccine for SARS-Cov-2.
The most likely cause of death of Hercule Poirot, the fictional Belgian detective created by Agatha Christie, was advanced coronary heart disease due to several cardiovascular risk factors. To investigate this hypothesis, the authors scrutinized all Agatha Christie books which included Poirot as their main character and examined his lifestyle and physical symptoms. Although the English writer was likely unaware of the now well-known links between Poirot's lifestyle and his exitus, considering the predominant therapeutic options for cardiovascular disease when the books were written and comparing them with Poirot's life, the authors were able to establish the severity and progression of his illness. Agatha Christie's novels also provide some unexpected information on knowledge regarding cardiovascular diseases in the twentieth century.
implementation, in accordance with the Colombian requirements and regulations in this matter, having a recent policy and advancing in the design of processes, procedures and manuals; There are no tangible results of the evaluation of the system and specific improvement actions. Discussion There is a need to refine the planning and implementation of strategies that contribute to the proper implementation of the SGSST; To train a greater number of the brigade, minimising the impact by the rotation of the staff. Disseminate in greater degree the politics, strategies and activities in the university community. It is necessary to design workshops according to their functions that allow them to make use of the protection elements available to them, since their perception shows that the main cause of accidents is caused by human errors. Introduction Settlement and integration involves helping recent immigrants and refugees find work and become economically solvent. Yet many newcomers end up in 'survival jobs' that are precarious, physically demanding and expose workers to hazards. While 'welcome materials' and settlement programs help newcomers find employment, few offer guidance on employment rights, employer responsibilities and how to stay safe at work. We know very little about how newcomers prepare for employment, the types of resources needed or which groups are well-positioned to deliver these resources. Methods Semi-structured interviews were conducted with policy makers, program developers, social service providers involved in immigrant settlement and employment preparation (n=20). Eighteen focus groups were also conducted with newcomers looking for work and those who had found their first jobs in Canada. The study examined the employment preparation and job search process; newcomer experiences in their first jobs; key training and resource needs related to safe work integration. Data were coded by two researchers and a thematic, inductive analysis was carried out. The constant comparative method was used to understand how newcomers come to understand their rights and where there are gaps in resources and training. Findings Our findings suggest that while many programs focus on employment preparation, the delivery of OHS and rightsrelated resources is haphazardly and hampered by a lack of consistent funding, time constraints and a diffusion of responsibility. Newcomers reported difficulty finding work and taking jobs that were incommensurate with their experience and education. Many took on informal work without training or compensation as a means of gaining Canadian experience. Participants had poor understanding of rights and responsibilities in the workplace and many had not received comprehensive OHS training. The use of community networks, while useful in finding employment, could be a barrier to speaking up in the workplace. Language barriers were an obstacle to finding work and invoking workplace rights. Discussion This study adds to our understanding of what can help recent immigrants and refugees succ...
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