ResumenSe administró clozapina a 28 esquizofrénicos resistentes al tratamiento en los servicios psiquiátricos en Bolonia. A las 26 semanas, el 62% de los pacientes mostraba respuesta. Los síntomas positivos y negativos mejoraron, pero la disminución de los síntomas negativos dependía en parte de la mejoría de los positivos y los extrapiramidales. No se vieron casos de agranulocitosis. Algunos abandonos estaban relacionados con dificultades con la mejoría psicopatológica.
Clozapine was administered to 28 resistant schizophrenics at psychiatric services in Bologna. At 26 weeks 62% responded. Positive and negative symptoms improved, but decrease of negative symptoms partially depended upon improvement of positive and EPS. No cases of agranulocytosis were seen. Some drop-outs were related to difficulties with psychopathological improvement.
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