ABSTRACT:The current study was aimed at evaluating the effect of heat stress (during the hot-dry period) on some physiological variables, haematology and erythrocyte osmotic fragility (EOF) in bucks, pregnant (single and twin) and lactating Red Sokoto (RS) goats. Forty apparently healthy adult goats were used for the study and were allotted to four groups [bucks (n = 10), pregnant (n = 10) dry (n = 10), and lactating (n = 10) does]. The pregnant goats were further re-grouped according to number of foetuses (single foetus, n = 5 and twins, n = 5). The temperature-humidity index and physiological variables measured were significantly higher in the afternoon compared to morning hours. Pregnant does had higher respiratory and pulse rates than the dry does, but no significant change (P > 0.05) in rectal temperature was observed between groups. On the basis of sex, bucks had lower (P < 0.05) mean corpuscular volume (MCV) than other groups, in addition to having higher (P < 0.01) mean corpuscular haemoglobin (MCH) and total leucocyte counts than dry does. Pregnant does exhibited significantly lower (P < 0.05) packed cell volume, but significantly higher (P < 0.05) MCH and mean corpuscular haemoglobin concentrations (MCHC) than lactating does. Does with a single foetus had significantly lower (P < 0.05) MCV, but higher MCHC than does with twin pregnancies. Using EOF as a biomarker of oxidative stress, erythrocytes of bucks were significantly more resistant to hypotonic haemolysis than those of dry, pregnant and lactating does, with no significant difference in EOF between does of different groups. The erythrocytes of single and twin pregnancies showed similar haemolysis pattern. In conclusion, sex, lactation, and the number of foetuses carried by pregnant does significantly influences physiological and haematological variables in RS goats during the hot-dry season. Also, during heat stress, the changes in physiological variables seem to enhance favourable adaptation by preventing an increase in rectal temperature even in twin pregnancies.
C2 domains, C2A and C2B (Fukada and Mikoshiba, 2001). Initially, the C2 domains were identified as protein structural domains for calcium-dependent protein kinase C (Duncan et al., 2000; Corbalan-Garcia et al., 2014). However, further data delineated other roles of C2 domains including cellular signal transduction and other protein-protein interactions (Farah and Sossin,
Background: It has been estimated that 5% of the global population are carriers of Hemoglobin (Hb) disorders. These disorders may cause hemolytic anemia leading to the critical condition of the patients. The current research was designed to identify spectrums of thalassemia minor and carriers of other hemoglobinopathies patients presenting at the tertiary care center to evaluate anemia. Methodology: A total of 3289 patients’ data with low Hb values and suspicion of hemoglobinopathies were included in this cross-sectional retrospective study. Complete blood count (CBC), High-performance liquid chromatography (HPLC), and sickling test were utilized in this study. At the same time, Patients with normal Hb as per HPLC analysis were excluded from this study. Results: Of the total, 708 (21.5%) patients had hemoglobin disorder and the mean age of patients with thalassemia minor was 24.0 ± 14.7 years. Out of 708 carriers, 646 (19.6%) cases showed traits of thalassemia minor, 12 (0.36%) showed Hb S trait, 43 (1.30%) showed Hb D trait, 07 (0.21%) showed Hb E trait, whereas there were no cases of Hb C recorded in this study. Conclusion: Thalassemia trait was the highest among other variants in our study population. It is recommended that to decrease the frequency of hemoglobinopathies, pre-marriage screening should be conducted, and family marriages should be restricted.
IntroductionDue to the COVID-19 pandemic, there is a steep rise in the acceptance of telemedicine and digital health, including increased interest in pursuing mental health treatment through telepsychiatry. Digital health helps following social distancing measures and increases the health outcomes.ObjectivesTo see the role of digital health in improving physical and mental well-being during COVID-19 PandemicMethods This study is a part of a large global project where 240 people inquired advice on phone app during COVID-19-Pandemic. Later on, a short study was conducted on the same population through survey to evaluate the effectiveness of digital health/tele-mental health. We also searched PubMed, Google Scholar, PsychInfo, and Medline for words “Digital Health, Tele-mental health, COVID-19-Pandemic”. Reviewed 40 articles and included 3 in this review1,4,5.Results We received a total of 98 responses. 65.6% people reported that online health resources are helpful in relieving pandemic-induced anxiety/stress, 66.2% reported to continue online health services after pandemic, 37.7% noted that digital health saves times in waiting areas, 46% reported lack of physical interaction with doctor as a disadvantage of digital health, and 40.3% reported comfort in using tele-mental health. Our literature review has shown barriers like privacy concerns and technological issues1. Provision of tele-psychiatry is safe and effective in continuity of mental health care.4,5Conclusions There has been an increased inclination towards digital health during any disaster. During COVID-19-Pandemic, digital health has increased access to mental health care and reduced risk of infection. The drawbacks include poor patient-doctor relationship, reimbursement concerns, and lack of confidentiality.
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