Alzheimer’s disease is an incurable neurodegenerative disease primarily affecting the elderly population. Efficient automated techniques are needed for early diagnosis of Alzheimer’s. Many novel approaches are proposed by researchers for classification of Alzheimer’s disease. However, to develop more efficient learning techniques, better understanding of the work done on Alzheimer’s is needed. Here, we provide a review on 165 papers from 2005 to 2019, using various feature extraction and machine learning techniques. The machine learning techniques are surveyed under three main categories: support vector machine (SVM), artificial neural network (ANN), and deep learning (DL) and ensemble methods. We present a detailed review on these three approaches for Alzheimer’s with possible future directions.

In this paper, a deep-learning-based driver-drowsiness detection for brain-computer interface (BCI) using functional near-infrared spectroscopy (fNIRS) is investigated. The passive brain signals from drowsiness were acquired from 13 healthy subjects while driving a car simulator. The brain activities were measured with a continuous-wave fNIRS system, in which the prefrontal and dorsolateral prefrontal cortices were focused. Deep neural networks (DNN) were pursued to classify the drowsy and alert states. For training and testing the models, the convolutional neural networks (CNN) were used on color map images to determine the best suitable channels for brain activity detection in 0∼1, 0∼3, 0∼5, and 0∼10 second time windows. The average accuracies (i.e., 82.7, 89.4, 93.7, and 97.2% in the 0∼1, 0∼3, 0∼5, and 0∼10 sec time windows, respectively) using DNNs from the right dorsolateral prefrontal cortex were obtained. The CNN architecture resulted in an average accuracy of 99.3%, showing the model to be capable of differentiating the images of drowsy/non-drowsy states. The proposed approach is promising for detecting drowsiness and in accessing the brain location for a passive BCI.INDEX TERMS Drowsiness detection, functional near-infrared spectroscopy, deep neural network, convolutional neural network, brain-computer interface.

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