This work investigates the association between longevity, mitochondrial DNA (mtDNA) variants and oxidative DNA damage in an older than 85 years population. The participants, similar in genetic and cultural background as well as gender distribution, come from villages near to the Pyrenees Mountains (900-1,400 m altitude) (n = 69) and the Ebro's Valley (200-300 m altitude) (n = 69) in Spain. Our results show an accumulation of the haplogroup J in elderly individuals with an over-representation of J2 in Pyrenees group but not in the Ebro's Valley, the former associating with a diminished DNA damage. In conclusion, our results suggest that J mitochondrial variant, that induce lower mtDNA damage, could present a phenotypic survival advantage to environmental conditions and, thus, accumulate in elderly population.
our patient sustained two respiratory arrests related to the use of narcotics. Therefore, avoidance of hypnotics and narcotics in this group of patients is strongly recommended. Recognition of the fact that adult-onset nemaline myopathy may present with pulmonary symptoms due to diaphragmatic paralysis rather than muscle weakness is of utmost importance to the clinician, since these patients, otherwise, might be subjected to unnecessary and often invasive investigations or inappropriate therapy.
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