Heparin extracorporeal low‐density lipoprotein precipitation (HELP) Futura is a new development in the standard HELP Secura system that has been in clinical practice for more than 15 years. Based on this experience, a HELP Upgrading system was first evaluated in a clinical trial to confirm the same clinical results as in the standard system. The upgraded procedure worked with industrially prepared sterile dialysis solutions instead of the reverse osmosis device. The conclusion of the study was that the reductions of low‐density lipoprotein, lipoprotein (a), and fibrinogen and the correction of the acid‐base balance were comparable with the results of the standard system. As a second step, the HELP Futura system was evaluated in a clinical acceptance test and in a field test in the daily routine. After approximately 2,000 treatments on 35 patients, we can conclude that the HELP Futura procedure has reached a mature phase with a high degree of clinical safety and flexibility.

Introduction: While the role of early mobilization in the immediate postinfarction period has been well demonstrated, little is known in present about the link between early mobilization and reduction of systemic inflammation. At the same time, the impact of early mobilization on regression of left ventricular remodeling has not been elucidated so far.Material and methods: Here we present the study protocol of the REHAB trial, a clinical descriptive, prospective study, conducted in a single-center, with the purpose to analyze the impact of early mobilization in reducing left ventricular remodeling, the complication rates and mortality in patients who had suffered a recent acute myocardial infarction (AMI). At the same time, the study aims to demonstrate the contribution of early mobilization to reduction of systemic inflammation, thus reducing the inflammation-mediated ventricular remodeling. 100 patients with AMI in the last 12 hours, and successful revascularization of the culprit artery within the first 12 hours after the onset of symptoms in ST-segment elevation acute myocardial infarction or within first 48 hours in non ST-segment elevation AMI will be enrolled in the study. Based on the moment of mobilization after AMI patients will be distributed in 2 groups: group 1 patients with early mobilization (<2 days after the onset of symptoms) and; group 2subjects with delayed mobilization after AMI (>2 days after the onset of symptoms). Study outcomes will consist in the impact of early mobilization after AMI on the ventricular remodeling in the post-infarction period, as assessed by cardiac magnetic resonance imaging, the rate of in-hospital mortality, the rate of repeated revascularization or MACE and the effect of early mobilization on systemic inflammation in the immediate postinfarction phase. Conclusion:In conclusion, REHAB will be the first trial that will elucidate the impact of early mobilization in the first period after AMI, as a first step of a complex cardiac rehabilitation program, to reduce systemic inflammation and prevent deleterious ventricular remodeling in patients who suffered a recent AMI.

Background: Physical rehabilitation is essential to improve the quality of life of patients with acute myocardial infarction (AMI).Study aim: The study intended to demonstrate the benefits of early rehabilitation in patients with AMI.Material and method: We performed a meta-analysis to document the benefits of physical treatment in patients who suffered an AMI. Studies were searched in the following databases: PubMed, PlosOne, Mendeley, and clinicaltrials.gov. The terms used in our research were “rehabilitation”, “physical exercise”, “physical training” “quality of life”, “early”, and “post MI”. The inclusion criteria consisted in the assessment of the following parameters: heart rate, maximal/submaximal capacity, and characteristics of the left ventricle – end-diastolic volume, ejection fraction, and left ventricle hypertrophy included in the study design.Results: The database search identified 710 studies, of which only 10 passed the inclusion criteria. Out of 1,515 patients who underwent early physical therapy, 960 reported improvement in the quality of their life (p <0.001). A number of 2,703 patients out of a total of 3,595 underwent a complete physical treatment and medication program. From the ten studies included in the meta-analysis, six had a positive feedback to the multimodal treatment within 1 month post-AMI. Patients who performed physical exercises within a month after the cardiac arrest (1,103 post-AMI patients from a total of 1,278) demonstrated a high heterogeneity represented by the coefficient I2 = 84% but with a significant statistical value of p <0.00001.Conclusion: Early physical therapy initiation significantly improves the quality of life of patients with AMI.

Translation of the Bible or any other text unavoidably involves a determination about its meaning. There have been different views of meaning from ancient times up to the present, and a particularly Enlightenment and Modernist view is that the meaning of a text amounts to whatever the original author of the text intended it to be. This article analyzes the authorial-intent view of meaning in comparison with other models of literary and legal interpretation. Texts are anchors to interpretation but are subject to individualized interpretations. It is texts that are translated, not intentions. The challenge to the translator is to negotiate the meaning of a text and try to choose the most salient and appropriate interpretation as a basis for bringing the text to a new audience through translation.

No abstract