No abstract

Keywords:Rupatadine is a once-daily, non-sedating, selective and long-acting new drug with a strong antagonist activity towards both histamine H1 receptors and plateletactivating factor receptors. The use of rupatadine is indicated in adult and adolescent patients (> 12 years of age) suffering from intermittent and persistent allergic rhinitis. In the treatment of these conditions, rupatadine is at least as effective as ebastine, cetirizine, loratadine and desloratadine. Avery good safety profile of rupatadine has been evidenced in various studies, including a long-term (1-year) safety study. Rupatadine does not present drug-drug interactions with azithromycin, fluoxetine and lorazepam, but should not be administered concomitantly with known CYP3A4 inhibitors.antihistamine, platelet-activating factor, rhinitis, rupatadine.

No abstract

No abstract

A new concept—that of pseudoconsistency—which seems to be particularly appropriate for the estimation of a quantile is introduced. It is shown without any conditions whatsoever on the underlying distributionthat the sample quantile is strongly pseudoconsistent for the corresponding population quantile. The asymptotic distribution of the sample quantiles and order statistics is derived when the underlying distribution is discrete.