An improved, simple, and facile synthesis of amidoalkyl naphthols by employing three-component one-pot condensation reaction of β-naphthol, aromatic aldehydes, and amides in ionic liquids using ytterbium triflate as a mild Lewis acid catalyst is described. Advantageously, amidoalkyl naphthols were obtained in high yield under eco-friendly, economical, and non-corrosive conditions, and the catalyst was recycled.

The synthesis of novel imidazolium ionic liquid, tagged Schiff, has been described. The synthesis was achieved in three steps from 2,4-dihydroxybenzaldehyde by selective alkylation with 1,3-dibromopropane, followed by reaction with 1-methylimidazole and Schiff base formation with aromatic amines. The compounds were evaluated for antibacterial and antifungal activities. The ionic liquid tagged Schiff base 4a showed the inhibition of both Gram positive and Gram negative bacteria. It also showed broad spectrum antifungal activity against all four tested fungi; however, 4f showed highest antifungal activity against A. niger.ß 2012 Published by Elsevier Masson SAS on behalf of Acade ´mie des sciences.

An efficient, one-pot synthesis was developed for 3-aminoalkylated indoles by three-component coupling reaction of aldehydes, N-methylanilines, and indoles using AgOTf as a catalyst. A series of twenty 3-aminoalkylated indoles was evaluated for their antibacterial activities against both Gram negative and Gram positive bacteria. Compounds 4b and 4r showed good antibacterial activity against both Gram positive and Gram negative strains. However, inversing the property of substituent (from 4r to 4q) resulted in the significant fall in the magnitude of antibacterial activity against Escherichia coli.

An efficient synthesis of 1‐(benzothiazolylamino)methyl‐2‐naphthols has been developed in water by one‐pot condensation of 2‐naphthol, aldehydes and 2‐aminobenzothiazole catalyzed by sodium dodecyl sulfate. Advantages of the methodology include a very short reaction time, excellent yields and catalytic use of the sodium dodecyl sulfate.

in Wiley Online Library (wileyonlinelibrary.com).Isomerization of 2 0 -hydroxychalcone and 2 0 -aminochalcone have been investigated using ytterbium(III) trifluromethanesulfonate {Yb(OTf) 3 } (30 mol %) as Lewis acid catalyst in [bmim] [BF 4 ] ionic liquid. The effect of different metal triflates as Lewis acid, catalyst loading and reaction media was studied for this isomerization reaction. Advantages of the methodology include short reaction time, excellent yields, catalytic use of Lewis acid, and recovery and reuse of the catalyst.Scheme 2. A plasible mechanism for isomerization of 2 0 -hydroxychalcones and 2 0 -aminochalcones. 1358Vol 48