The burden of neurodegenerative diseases is emerging with the increase in life expectancy. It is a great challenge to develop effective methods of preventing these diseases and to treat them. Quinoline and its derivatives have numerous biological effects. They show significant anti-neurodegenerative activity. Quinoline compounds are used to develop various anti-neurodegenerative drugs as they have demonstrated fantastic effects through numerous mechanisms of action. A lot of quinoline compounds have been studied till now for their anti-neurodegenerative properties. Quinoline scaffold among all heterocyclic compounds has emerged as a critical building block for the production of a variety of novel medications.Many heterocyclic substituent quinoline derivatives with good anti-neurodegenerative activity are discussed in this review. Such as PBT2 that has shown potential to reduce cerebrospinal fluid Aβ, and improve cognitive functions, quinoline-chromenone and acridine-chromenone hybrids that act as anti AChE agents. Further molecules like coumarin-quinoline derivatives, 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes and Clioquinol has been discussed as a possible anti-Neurodegeneration medication. The efficacy of quinoline derivatives to cure neurodegenerative diseases and save the central nervous system in early stage has nurtured the interest of researchers to increase the search in this area.