Giant onychomatricoma is a rare fibroepithelial nail matrix tumor with only two previous reports in literature, from Mexico. An 80-year-old female patient presented with a progressively painless mass in the left great toe nail, following trauma, of 2 years duration. On examination there was a single, hard, immobile mass of size 4 × 3 × 2 cm with proximal hyperpigmentation of the left great toe nail. The mass was totally excised and a punch biopsy of nail matrix was taken. Histopathology revealed hyperkeratosis, acanthosis, multiple channels lined by flattened epithelium and fibrocollagenous tissue in horizontal orientation in deeper layers. The patient had no recurrence after 1 month. We report this case for its rare and distinct clinical presentation, characteristic histopathology and easy surgical treatment.
Aprepitant is a recently introduced NK1 receptor antagonist. It effectively blocks Substance-P, which is supposed to have emetic action. Hence, this newer drug is being used in patients undergoing chemotherapy to prevent chemotherapy induced nausea and vomiting (CINV). This particular review article gives a bird's eye view on aprepitant, which is being tried as an adjuvant anti emetic in patients with far advanced cancer.
cAse seRIes INTRoDucTIoNFixed drug eruption is a type of cutaneous adverse drug reactions accounting for 4-39% of all drug eruptions worldwide. [1] Paucity of data in Indian population but a systemic review reported its incidence as 20.13% amongst Cutaneous Adverse Drug Reactions. [2,3] Here we present a collection of cases observed in our patients.
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