Purpose: To determine whether the location of a culprit ruptured varix increases rebleeding risk after ePTFE-covered stent transjugular intrahepatic portosystemic shunt (TIPS) placement. Materials: We retrospectively reviewed 136 patients who underwent TIPS for acute variceal hemorrhage between Jan 2005 and Jun 2015. Varices were categorized as esophageal (E, n ¼ 71), gastric (G, n ¼ 52), or other (O, n ¼ 13; colonic, duodenal, parastomal, or rectal) based on endoscopic or surgical localization of identified hemorrhage. Patient ns demographics, MELD score, follow-up time, mean final portosystemic gradient (PSG), adjunctive procedures to occlude varices, and variceal rebleeding rates were recorded and analyzed. Continuous and categorical variables were analyzed using ANOVA, Chi-squared tests, Fisher's exact tests, and logistic regression in SAS (SAS Institute, Cary, NC). Results: Demographic characteristics and pre-procedural MELD scores were similar among the 3 groups. Intraprocedurally, patients with gastric varices were more likely to undergo adjunctive procedures to occlude varices than patients with esophageal or other varices (54.9% E vs 78.9% G vs 69.2% O, p ¼ 0.03), though final PSG values were similar in each group (7.2 mmHg E vs 6.3 mmHg G vs 5.8 mmHg O, p ¼ 0.11). No significant difference in variceal rebleeding rates was evident (14.3% E vs 9.6% G vs 15.4% O, p ¼ 0.68). Similarly, rebleeding odds did not significantly differ after adjustment for intraprocedural adjunctive procedures to occlude varices (G vs E OR 0.85, p ¼ 0.79; O vs E OR 1.29, p ¼ 0.77). Mean follow-up times were similar among all groups (20.8 months E vs 15.5 months G vs 14.9 months O, p ¼ 0.48). Conclusions: The location of pre-TIPS variceal hemorrhage does not significantly affect rebleeding rates after TIPS creation for esophageal, gastric, or other varices. Data are limited by low number of adverse events and short followup interval.