Abstract:: The outer layer of skin and underlying soft layer of tissues have been infected by several infections locally. Infection on local tissue can be overcome by administration of various topical formulations such as nanoemulgel, niosomal gel, liposomal gel etc. For obtaining the significant effect of drug delivery, nanoemulgel exhibits high intensity of activity locally. Emulsion with uniform and extremely small droplet size in the range of 20-200 nm is referred as nanoemulsion. The emulsion may be oil in water or water in oil type. This system can improve the permeation of drug substances through the skin. Nanoemulsion incorporated into a gel base to form Nanoemulgel and can improve the permeation of drug sub-stances through the skin. Nanoemulgel acts as a promising carrier of intense amount of permitted drugs to produce their effect topically. Efficient adhesion property and immense solubilising of drug in oil or water phase leads to larger concen-tration gradient towards the skin that further increase the penetration of drug substances through skin. This study provides useful insights on the utilisation of nanoemulgel to provide a better and effective drug delivery tool for the topical system.