To find out the pattern of dental diseases and drug utilization at dental out patientdepartment (OPD) of B.P. Koirala Institute of Health Sciences (BPKIHS), a tertiarycare hospital. A prospective prescription audit was conducted for a period of 10 daysin the dental OPD and the data was analyzed using WHO drug indicators. The totalnumber of prescriptions analyzed were 279. Dental caries (37%), Periodontitis (14%)and chronic gingivitis (11%) were the most common diseases with a maximum incidencebetween the age groups of 9 to 40 years. Mean number of drugs per prescription was2.79. Of the total prescriptions, 223 (79.9%) had 314 antimicrobial agents (AMA)constituting 40.3% of total drugs prescribed. The mean number of antimicrobial agentsper prescription was 1.13. The most commonly prescribed antimicrobial agents wasamoxycillin (33.1%) followed by metronidazole (24.9%), doxycycline (17.2%) andtinidazole (12.7%). Fixed dose drug combination of amoxycillin + cloxacillin (26) andampicillin + cloxacillin (10) were prescribed in 36 of the prescriptions. Povidone iodinegargle (41.2%) was the most commonly prescribed oropharyngeal preparation followedby Chlorhexidine gluconate mouthwash (32.4%). Non- steroidal anti-inflammatoryagents (20.66%), multi-vitamins (19.51%) and oropharyngeal preparations (17.45%)constituted the rest of the drugs prescribed. Diclofenac (60.86%) was the mostcommonly prescribed among NSAIDs and fixed dose drug combination of ibuprofenand paracetamol was prescribed in 19 of the prescriptions. All drugs were given byoral route (except for gentamicin in one prescription) and were prescribed underbrand names. None of the prescriptions had instructions whether the drug should betaken before or after food. The results indicate that dental caries was the most commondental disease, anti-microbial agents were prescribed to majority of the patients andconstituted a little less than half of the total drugs prescribed. Commonly used anti-microbial agent was amoxycillin which in two thirds of the cases was prescribed as anfixed dose drug combination. The high incidence of anti-microbial agent prescribingmay be modified by a feedback to the prescribers.Key words: Dental morbidity, prescribing pattern, drug utilization, dental OPD,antimicrobial agents.