The subcutaneous injection of diethylstilbestrol (2.5 µg/day) into pregnant guinea pigs from the 28th or 40th day to term resulted in an accelerated tempo of differentiation of the genital tract of the female offspring at birth, as well as intense estrogenic stimulation. Estradiol (50 µg per day) injected over the same period caused insignificant estrogenic stimulation in the newborn. The normal embryogenesis of the genital tract is described and a pattern of caudocranial differentiation identified. The normal genital tract is described as a basis for the analysis of results in the newborn. Comparative studies in other animals are discussed.
increased the proteinuria, while a diet with only 5% casein diminished it markedly.Since the proteinuria in mice is associated with sex, the effect of castrating young male mice was studied. The degree of proteinuria remained unchanged for many weeks following the operation, but was greatly decreased after about 3 months. Addis' has reported a similar result for albumintiria of male rats. Bell" noticed the appearance of albuminuria as young male rats reached maturity. Our rats show no excretion of protein, and we have found very little mention of any marked proteinuria of these animals.In connection with the apparent sex-linked character of the proteinuria of mice, the recent report of Crabtree-tl is of great interest. She observed differences in structure of Bowman's capsule between most male and female mice. She cites the experiments of Selye,12 who noticed that treatment of female mice with testosterone propionate may change the parietal lamina of Bowman's capsule, Summary. A protein with chemical characteristics of a nucleoprotein was found to be excreted in large amounts by male mice of various ages and strains. Female mice excrete much less protein, frequently none at all. A table is appended.For the castration of animals and the examination of sections, I am much indebted to Dr. William Cramer.The influence of the method of administration upon the duration of the effect of estrogenic compounds has early been recognized 9
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