Indapamide-SR-based therapy is equivalent to enalapril-based therapy in reducing microalbuminuria with effective blood pressure reduction in patients with hypertension and type 2 diabetes.
Electrical alternuns at the repolarization phase of the cardiac cyclc: have been reported to be related with increased risk for ventricular arrhythmias (VA). I n this work we present and stud!y a method for detecting S T -T complex alternans based on the Karhunen-Lodve ( K L ) transform and a beatquency transform (Fourier transform of KL series with beat order as temporal reference). The ratio of the power in the band around 0.5 cycles/beat respect to the total power is then used as indicator of the period 2 alternans presence. Similarly is done j%r period 4 alternans. To study the performance of
this detection system we have generated a simulated alternating ECG with added noise (moving artifacts, E M G and baseline wander noise). The results for SNR around 15 dB at ST-T complex (normal value at ECG signals) give a sensitiv-ity and specificity for period 2 alternans detection over 95%. This mer.hod appleed to the entire European S T -T database gives 25 a1ternatin.g episodes, 56% corresponding to ischemic episodes, showing that 5.3% of the ischemic episodes include alternan:; episodes.
Background: Blood pressure control is the main influential variable in reducing microalbuminuria in patients with type 2 diabetes. In this subanalysis of the Natrilix SR versus Enalapril Study in hypertensive Type 2 diabetics with micrOalbuminuRia (NESTOR) study, we have compared the effectiveness of indapamide sustained release (SR) and enalapril in reducing blood pressure and microalbuminuria in patients ≥65 years of age.
What is known and objective: In paediatrics, evidence regarding the treatment of viral myocarditis using interferon beta-1B is restricted to four children older than two years and there are no reported cases of infants. The objective was to describe the efficacy and safety of interferon beta-1B in two infants under one year of age with viral myocarditis. Case summary: Two infants were admitted to the hospital presenting with respiratory symptoms. Echocardiogram showed myocardial damage. Parvovirus-B19 was detected using a PCR assay, and treatment with interferon beta-1B was initiated. Six months later, the cardiac function had recovered in both cases.What is new and conclusion: This is the first published series of cases of infants less than 1 year of age with viral myocarditis treated with interferon beta-1B.
| 863CANALES SIGUERO Et AL. revealed moderate-severe left ventricular dysfunction (left ventricular ejection fraction (LVEF) Simpson BP: 39%), left ventricular dilatacion, and severe mitral insufficiency. Additionally, markers of myocardial damage were altered: troponin T 228 ng/L (≤14 ng/L) and NT-proBNP >70.000 pg/mL (≤125 pg/mL). As acute myocarditis was suspected, supportive treatment was initiated, and blood samples were drawn for aetiological study.Empirical antibiotic treatment with cefotaxime 200 mg/kg/ day and intravenous immunoglobulins was initiated. Furthermore, adrenaline (0.05 µg/kg/min), levosimendan, furosemide and spironolactone were administered as supportive treatments.
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