Postoperative knee instability was less common after ACL reconstruction with patellar tendon autograft than with hamstring tendon autograft.

We conclude that the use of hamstring grafts for ACL reconstruction can lead to different histological pattern of tendon-bone healing. Micromotion of the hamstring graft inside the drilled canal can be play a role in tendon-bone healing.

No abstract

Isolated patellofemoral osteoarthritis in the healthy middle-aged population is a challenging problem. Fifty-one knees in 50 patients with isolated patellofemoral osteoarthritis were treated by partial lateral facetectomy, lateral release, and medialization of the tibial tubercle. The minimum followup was 7 months (mean, 20.2 months; range, 7-32 months

BACKGROUNDVascular endothelial growth factor (VEGF)‐A and angiopoietin (Ang)‐1 and Ang‐2 are key factors in angiogenic signaling. In this study the expression of these factors was identified in cartilage tumors. As interleukin (IL)‐1β has been found to be an indispensable factor in angiogenic signaling, we further analyzed the effect of IL‐1β on the expression of VEGF‐A, Ang‐1, and Ang‐2 using a previously established cell culture model.METHODSSurgical specimens of enchondromas, conventional chondrosarcomas, and dedifferentiated chondrosarcomas were obtained from 72 patients. VEGF‐A, Ang‐1, and Ang‐2 mRNA expression was detected by conventional and quantitative reverse transcription polymerase chain reaction (PCR). VEGF‐A expression was also detected by immunohistochemistry or Western blot.RESULTSDifferential expression of VEGF‐A, Ang‐1, and Ang‐2 was clearly demonstrated in cartilage tumors. VEGF‐A expression was positively correlated with the tumor type. Higher VEGF‐A expression levels were detected in conventional chondrosarcomas Grades II and III (using a 3‐tier grading system) than in dedifferentiated chondrosarcomas (P < .05). A typical pattern of VEGF‐A isoforms was identified, including VEGF121, VEGF145, VEGF165, and VEGF189. Ang‐1 presented as a low‐level transcript with slightly elevated levels in chondrosarcomas (P < .05). Highly variable Ang‐2 expression levels were detected in solitary cases of conventional chondrosarcomas. IL‐1β regulated VEGF‐A and Ang‐1 expressions in a dose‐dependent manner. Whereas low IL‐1β concentrations increased VEGF‐A and Ang‐1 transcription, high IL‐1β concentrations had the opposite effect. IL‐1β did not activate Ang‐2 expression.CONCLUSIONSAngiogenic signaling in cartilage tumors is variable and at least partly regulable by IL‐1β. The findings are of therapeutic relevance, either as a desired effect or a side effect in medical treatment. Cancer 2006. © 2006 American Cancer Society.