BackgroundSurveillance of infectious diseases increasingly relies on Geographic Information Systems (GIS). The integration of pathogen fine typing data in dynamic systems and visualization of spatio-temporal clusters are a technical challenge for system development.ResultsAn online geographic information system (EpiScanGIS) based on open source components has been launched in Germany in May 2006 for real time provision of meningococcal typing data in conjunction with demographic information (age, incidence, population density). Spatio-temporal clusters of disease detected by computer assisted cluster analysis (SaTScan™) are visualized on maps. EpiScanGIS enables dynamic generation of animated maps. The system is based on open source components; its architecture is open for other infectious agents and geographic regions. EpiScanGIS is available at , and currently has 80 registered users, mostly from the public health service in Germany. At present more than 2,900 cases of invasive meningococcal disease are stored in the database (data as of June 3, 2008).ConclusionEpiScanGIS exemplifies GIS applications and early-warning systems in laboratory surveillance of infectious diseases.
Abstract. In real-time rendering, objects are represented using polygons or triangles. Triangles are easy to render and graphics hardware is highly optimized for rendering of triangles. Initially, the shading computations were carried out by dedicated hardwired algorithms for each vertex and then interpolated by the rasterizer. Todays graphics hardware contains vertex and pixel shaders which can be reprogrammed by the user. Vertex and pixel shaders allow almost arbitrary computations per vertex respectively per pixel. We have developed a system to evolve such programs. The system runs on a variety of graphics hardware due to the use of NVIDIA's high level Cg shader language. Fitness of the shaders is determined by user interaction. Both fixed length and variable length genomes are supported. The system is highly customizable. Each individual consists of a series of meta commands. The resulting Cg program is translated into the low level commands which are required for the particular graphics hardware.
On October 5th, 2006, the German Reference Centre for Meningococci (NRZM) held the 3rd Workshop on Epidemiology, Prevention and Treatment of Invasive Meningococcal Disease, in collaboration with the German Society for Hygiene and Microbiology (DGHM). Given the recent recommendation of the German Standing Committee on Vaccination (STIKO) for conjugate meningococcal C vaccination of all children in the second year of life, observations from meningococcal C conjugate vaccination campaigns in other European countries were presented and compared to the German situation. Moreover, the newly implemented cluster detection routines employed at the NRZM and their integration into the interactive geographical information system EpiScanGIS were shown. Based on recent experiences from regional outbreaks in Oberallgäu, Sangerhausen, and Greater Aachen, examples for public health intervention were given at the conference. In addition, current developments in the area of meningococcal research, as well as trends in antimicrobial susceptibility were covered. Finally, the latest evidence concerning the clinical management and chemoprophylaxis of this invasive bacterial disease was discussed.
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