Surgery for locally advanced vulvar cancer is often extensive with stoma formation or need for reconstructive surgery.• Definitive capecitabine-based chemoradiation is feasible with acceptable acute and late toxicity.• Local clinical complete response of 62% after 12 weeks and persistent local control of 42% after 2 years • Need for subsequent stoma formation in only 17% of patients.• Definitive chemoradiation can serve as alternative for extensive surgery in locally advanced vulvar cancer.
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