This study was undertaken to examine the long term relationship between lung function, smoking and exposure to enzymes in the detergent industry. A total of 731 male workers from five locations in the United Kingdom were subject to respiratory health surveillance including lung function testing over a period of 4-20 years. Exposure groups were defined by job history. Significantly different rates of fall in FEV1 and FVC with time were found by geographical location and by smoking habit, but there were no consistent trends with enzyme exposure.
Tumor cells are dependent on glutamine metabolism and acivicin, which is a selective glutamine antagonist, has been shown to effectively retard tumor growth in several malignancies. However, systemic treatment with acivicin is associated with significant side effects. The purpose of the present study was to examine whether use of an in vivo isolated liver perfusion model may allow administration of lethal doses of acivicin and compare it to regional infusion of acivicin in the hepatic artery. Five days after tumor inoculation, acivicin was administered by an isolated liver perfusion model or by regional infusion via the hepatic artery. It was found that regional infusion of acivicin (5 and 10 mg/kg) via the hepatic artery caused systemic illness and diarrhea, and all animals in this group died within 3 days. In contrast, we observed no signs of systemic illness, diarrhea or hepatocellular injury in rats receiving isolated liver perfusion with or without acivicin (10 mg/kg) administration. Noteworthy, we found that isolated perfusion with acivicin reduced the glutamine content in liver tumors by 39% compared to perfusion with control medium. In line with this, it was found that isolated perfusion with acivicin (10 mg/kg) inhibited tumor growth in the liver. Taken together, this study suggests that application of the isolated liver perfusion model avoids the toxic and lethal effects of high doses of chemotherapy, herein acivicin, and may provide a useful approach to treat liver tumors in vivo.
Results Based on the TAS 41% of boys showed higher than normal rates of alexithymia (A -40%,B -60%,C -100%). Among girls (75%,50%,43% respectively). AMR: 87%b and 82%g can't substantiate their goals. 50% of children had psychological barriers. Low-energy potential was recorded in Groups A and C (17% and 25%). 66% girls and 88% boys of all groups indicated optimal results. Scale of Rotter. Boys of Group C were dominated by external locus of control. Girls of such group were dominated by internal locus of control of life. Motivational pole is not strongly marked in 61% of girls.The analysis of TAS showed an increasing trend of alexithymia among boys (from 59% to 100%) and lower among girls (from 75% to 43%) with an increase in BMI. Boys with a BMI> 24 kg/m 2 prevailed external locus of control, the girls -internal locus of control. In analyzing the results of the questionnaire of Rean boys tended to reduce the motivation to succeed and grow with the increase of negative motivation with increasing BMI (success from 70% to 25%). Down syndrome (DS) is one the most common genetic disorders. Little is known about the impact of visual disorders in DS on daily life. Our aim was to study the relation between the incidence of ocular manifestations and adaptive behaviour. Methods We performed a detailed medical history, including ocular disorders. We tested Hirschberg's corneal reflex method, observed eye movements during fixation of a slowly moving object, cover test, and assessed the Vineland Adaptive BehaviourScales, as well as the Coloured Progressive Matrices. 52 DS individuals with an age range of 19 to 52 years. Results. We observed a high incidence of ocular anomalies (refractive errors in 59.2%, strabism in 51%, motility disorders in 63.3% and congenital bilateral cataract in 16.2%), not differing with age. The occurence of visual disorders did neither lead to total lower adaptive level nor show an influence on cognition. Daily living skills were significantly lower in individuals with not corrected disorders, but these individuals showed a significant high co-morbidity of autism with childhood onset. We observed a majority of individuals with an adaptive functioning above the average. Hyperopia and the presence of refractive errors were significantly more frequent in individuals with an adaptive level above the average. Conclusions. Visual disorders lead to a poorer performance in adaptive behaviour in individuals with DS and also autism. This suggests that early intervention on refractive errors and visuomotor skills helps in the acquisition of daily living activities, which remain stable over the life-span. Therapeutic options for cataract need to be addressed early. Background and Aims Dimethylglycine, an amino-acid derivative, has been proposed as a treatment for Autism. A systematic review was conducted to synthesize the best evidence relating to this topic. EARLY INTERVENTION OF VISUAL IMPAIRMENT MAY WHAT IS THE EFFECTIVENESS OF DIMETHYLGLYCINE
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