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The mixed convection heat transfer around five in-line isothermal square cylinders periodically arranged within a vertical duct is numerically investigated in this paper. Spacing between two cylinders (S) is fixed at one width of the cylinder dimension (d) and the flow confinement of various degrees are studied for the blockage ratios of B = 0%, 10%, 25% and 50%. The buoyancy aided/opposed convection is examined for the Richardson number (Ri) ranges from -1 to +1 with a fixed Prandtl number Pr = 0.7 and Reynolds number Re = 100. The transient numerical simulation for this two-dimensional, incompressible, laminar flow and heat transfer problem is carried out by a finite volume based commercial CFD package FLUENT TM. The representative streamlines and isotherm patterns are presented to interpret the flow and thermal transport visualization. Additionally, the time and surface average skin friction coefficient (Cf), drag (CD) and lift (CL) coefficients as well as the time and surface average Nusselt number (Nu) for representative cylinders are determined to elucidate the effects of Re and Ri on the flow and heat transfer phenomena

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Neuroleptic malignant syndrome (NMS) is a rare, but fatal adverse reaction that is most commonly seen with typical antipsychotic medications. However, NMS can also be triggered by other dopamine-modulating agents that physicians are unlikely aware of, leading to being underdiagnosed or precluding early recognition of the syndrome. We describe a case involving a 20-year-old male who presented to the emergency department with altered mental status and failure to thrive. On admission, he subsequently developed an insidious onset of muscle rigidity and autonomic instability, and laboratory work-up was significant for leukocytosis, transaminitis, and elevations in creatinine phosphokinase, lactate, and C-reactive protein.After a battery of negative diagnostic tests, his clinical features fulfilled the NMS criteria by a diagnosis of exclusion, even in the absence of any antipsychotic regimen or dopaminergic medications. Management with dantrolene, amantadine, and aggressive fluid therapy provided a gradual return of the patient's baseline mentation along with normalization in laboratory assessments. In this novel case of NMS, we suspect oxcarbazepine and topiramate withdrawal as possible attributing factors for the patient's presentation. This article emphasizes the need for hypervigilance in future cases with high suspicion of NMS, in addition to raising a broader clinical awareness of other potential etiologies of NMS that are not restricted to only antipsychotic medications. We further discuss a review of the pathophysiology, various etiologies, clinical features, diagnostic criteria, treatment plans, and complications of NMS.

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In the present work, the effect of nanofluid in a shell and tube heat exchanger was studied numerically. The effects of Reynolds number, volume concentration of suspended nanoparticles on the heat transfer characteristics were investigated using CFD software. Finally, the effect of the nanofluid on Shell and tube heat exchanger performance was studied and compared to that of a conventional fluid (i.e., water).

A healthy 39-year-old man was referred with a 3-week history of nonresolving right upper eyelid cyst with no globe or orbital involvement. Histopathologic examination revealed a peripheral T-cell lymphoma of unspecified type, which was stage 3 on staging. He received combination cyclophosphamide, hydroxydoxorubicin, oncovin, and prednisolone therapy with an autologous bone marrow transplant and remains in complete remission 24 months posttreatment. A brief literature review of ocular adnexal T-cell lymphomas is presented.

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