Chemists have a great deal of attention towards modeling of cytochrome P450 monooxygenase using synthetic metalloporphyrins as they have a strapping resemblance to heme in both structures and catalytic property. The potential of the heme group is to combine with tiny ligands (including molecular oxygen) in enzymatic oxidations. In order to learn, the core of the heme group, the porphyrin ring with the central metal iron atom, has been selected. These complexes can catalyze the oxidation of aniline in simulating the function of cytochrome P450. Literature study 1-9 has revealed that halogenated metalloporphyrin complexes are excellent catalysts for difficult oxidations with high selectivity. Iron complexes of tetraphenylporphyrins, which has an intermediate structure sandwiched between common natural iron porphyrins with cytochrome P450. To complement the studies in the field of the catalytic oxidation of aniline, the oxidation of aniline by sodium perborate catalyzed by first generation catalyst mesotetraphenylporphyriniron(III) chloride (5,10,15,20-tetraphenyl-21h,23h-porphineiron(III) chloride) was taken for the study. Kinetics of oxidation of anilines by variety of oxidants has been reported 10-14 and only few of them authenticate Hammet equation. EXPERIMENTALThe catalyst meso-tetraphenylporphyriniron(III) chloride (Sigma Aldrich) was used as received. All chemicals and Heme-enzymes such as cytochromes P450 have ability to perform extremely difficult oxidations with high selectivity. The kinetic study of oxidation of aniline by sodium perborate with respect to the meso-tetraphenylporphyriniron(III) chloride reveals that there is a slow degradation of the catalyst in this oxidation reaction. The thermodynamic parameters for the oxidation have been determined and discussed. The increase in concentration of H + ions retards the rate of the reaction revealed that the protonated aniline is less reactive in this oxidation reaction. The sodium perborate oxidation with 12 meta-and para-substituted anilines complies with isokinetic relationship and Exner relationship but not to any of the linear free energy relationships. The solvent interaction plays a major role in governing the reactivity. A suitable mechanism and rate law was proposed for this reaction.
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