Background: Although the prevalence of both type 1 and type 2 diabetes mellitus is increasing worldwide, the prevalence of type 2 DM is rising more rapidly, because of sedentary lifestyle, increasing obesity and increased life expectancy. Objectives: To study correlation between fasting and postprandial triglyceride levels and Carotid artery intimal medial thickness (CIMT) in Type 2 Diabetic Patients. Material and Methods: This cross sectional observation study was done in Department of General Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India during January 2019 to June 2020. Sample size was 50 and Simple Random sampling method was used. Results: The mean carotid IMT of subjects with postprandial triglycerides < 200 with normal fasting triglyceride was 0.92±0.33. The mean carotid IMT of subjects with postprandial triglyceride 200-299 with normal fasting triglyceride was 1.52±0.57. The mean carotid IMT of subjects with postprandial triglycerides ≥300 with normal fasting triglycerides was 1.66±0.45. Conclusion: postprandial hypertriglyceridemia, despite normal fasting triglyceride levels, may be an independent risk factor for early atherosclerosis in type 2 diabetes. Hence evaluating not only for FTG but also PPTG level during clinical assessment of patients with type 2 diabetes is important.
Background: Poly-pharmacy being most common in chronic kidney disease patients (CKD). The present study was carried out to analyse current prescribing trends in the management of CKD patients and to compare it with WHO Core Indicators. Methods: A prospective observational study was carried out for three months (15th July 2019 – 15th October 2019) after Institutional Ethics Committee approval at a tertiary care hospital. Patients diagnosed with CKD by treating Nephrologist were included and their prescriptions (OPD card) were analysed to study the prescribing patterns. Results: A total of 60 cases were analysed during the study, of which 73.3% were males and 26.7% were females. The common comorbidities were hypertension (36.6%), diabetes (36.6%), other cardiovascular diseases (26.6%), anaemia (3.33%), Ca Cervix (1.67%), osteoarthritis (6.67%). Among drugs Antihypertensive drugs (40.9%) were the most commonly used drugs, followed by, Anti-diabetic drugs, calcium salts and multi-vitamins (19.7%), oral iron supplements and erythropoietin (13.4%) and ulcer protective (6.1%). Conclusions: Polypharmacy being followed in these CKD patients were necessary for multiple conditions of patient, supplemental drugs decreased adverse effects on initial drug and they yielded synergistic effects. Maximum numbers of drugs were prescribed from anti-diabetic, antihypertensive, supplemental drugs and other cardiovascular class of drugs. The principle of rational prescribing was followed. The right choice of drugs and in appropriate doses will reduce the incidence of nephrotoxicity and ultimately result better clinical outcomes.
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