The most prevalent pathology was lung cancer (19 CT, 14 of which were non-small cell lung cancer) and melanoma (four CT). Conclusion The CT are an opportunity to contain pharmaceutical costs in hospitals. Patients in CT produced a cost saving of C ¼ 3,482,662/year. The potential savings justify the need to incorporate as many clinical trials as possible, not just for cost savings but because it would mean better access for patients to these highly effective and/or breakthrough therapies.
partially used and perforated with a plastic spike, not PFL at room temperature. Material and methods The stability study was performed by high performance liquid chromatography coupled to a photodiode array detector. The method was validated according to the International Conference on Harmonisation guideline Q2 (R1). Physical stability was evaluated by visual and subvisual inspection. pH values were measured. Results PDA solutions PFL in D5W at 3 and 12 mg/mL retained more than 95% of the initial concentration after 7 days at 25°C and after 28 days at 2-8°C. PDA ready to dilute 25 mg/mL solutions PFL retained >95% of the initial concentration after 28 days at 25°C and 2-8°C. PDA solutions in D5W at 3 mg/mL and 12 mg/mL and PDA ready to dilute 25 mg/mL solutions not PFL retained >95% of the initial concentration after 7 days at room temperature. All samples had a pH in the range 8.05-8.77. A very light colouration, described in summary of product characteristics, to a more intense yellow-brown colouration, appeared depending on concentration and time. No precipitate was observed. Conclusion and relevance According to the manufacturer's specifications (colourless to slightly brown-yellow) and to the chemical stability, defined as >95% of the initial concentration, PDA solutions in D5W at 3 and 12 mg/mL and PDA ready to dilute 25 mg/mL solutions PFL were stable for 7 days at 25°C and for 28 days at 2-8°C. PDA solutions in D5W at 3 and 12 mg/mL and PDA ready to dilute 25 mg/mL solutions not PFL were stable for 7 days at room temperature.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.